Results 71 to 80 of about 23,834,518 (309)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Bio-Economy Concept and Knowledge Base in a Public Goods and Farmer Perspective [PDF]

, 2012
Currently an industrial perspective dominates the EU policy framework for a European bio-economy. The Commission’s proposal on the bio-economy emphasises greater resource-efficiency, largely within an industrial perspective on global economic ...
Padel, Susanne, Levidov, Les, Susanne Padel, Schmidt, Otto; Università di Bologna, Otto Schmidt, Levidow, Les, Schmid, Otto, Les Levidow   +7 more
core   +2 more sources

Room temperature phosphorescent wood hydrogel

Nature Communications
Room temperature phosphorescent (RTP) hydrogels exhibit great potential but show poor mechanical performance (Tensile strengthen
Ruixia Liu, Hongda Guo, Shouxin Liu, Jian Li, Shujun Li, Tony D. James, Zhijun Chen   +6 more
doaj   +1 more source

Gradient Structure Construction of High Thermal Conductivity Polyurethane/Boron Nitride Composite Fiber Membrane for Thermal Management

Molecules
Accompanied by the rapid progress of the digital era and the continuous innovation of material science and technology, wearable electronic devices are widely used in various industries due to their excellent portability and flexibility.
Zhengyang Miao, Jingwei Li, Yidan Liu, Fang Jiang   +3 more
doaj   +1 more source

A process for purifying xylosugars of pre-hydrolysis liquor from kraft-based dissolving pulp production process

Biotechnology for Biofuels, 2018
Background In the kraft-based dissolving pulp production process, pre-hydrolysis liquor (PHL) is produced, which contains hemicelluloses, lignin, furfural and acetic acid.
Jiachuan Chen, Jiran Dong, Guihua Yang, Ming He, Feng Xu, Pedram Fatehi   +5 more
doaj   +1 more source

Bio-Medical Library Bulletin, No. 100 (1989-04) [PDF]

, 1989
Bio-Medical Library. (1989). Bio-Medical Library Bulletin, No. 100 (1989-04).
Bio-Medical Library
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Zipper-inspired molecular polarity strategy enabling robust adhesive hydroplastics as sustainable plastic substitutes

Nature Communications
Hydroplastics with water-plasticizing effects and programmability are highly desired yet challenges arise from assembling renewable cellulose into hydroplastics with reversible adhesion and enhanced mechanical performance through water-enhancement ...
Guozhuo Chen, Chengling Huang, Yanjuan Dong, Yi Zheng, Yi Chen, Kam Chiu Tam, Hou-Yong Yu   +6 more
doaj   +1 more source

A General Synthesis Method for Patterning PEDOT toward Wearable Electronics and Bioelectronics

Research
The conductive polymer poly-3,4-ethylenedioxythiophene (PEDOT), recognized for its superior electrical conductivity and biocompatibility, has become an attractive material for developing wearable technologies and bioelectronics.
Wanke Cheng, Zihao Zheng, Xiaona Li, Ying Zhu, Suqing Zeng, Dawei Zhao, Haipeng Yu   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source