Results 91 to 100 of about 17,288,534 (269)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Bio-Medical Library Bulletin, No. 91 (1986-10)
, 1986 Bio-Medical Library. (1986). Bio-Medical Library Bulletin, No. 91 (1986-10).
Bio-Medical Library
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Bio-Medical Library Bulletin, No. 112 (1993-10)
, 1993 Bio-Medical Library. (1993). Bio-Medical Library Bulletin, No. 112 (1993-10).
Bio-Medical Library
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Bio-Medical Library Bulletin, No. 23 (1971-11)
, 1971 Bio-Medical Library. (1971). Bio-Medical Library Bulletin, No. 23 (1971-11).
Bio-Medical Library
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Tamper-Proof Time–Temperature Indicator for Inspecting Ultracold Supply Chain
ACS Omega, 2021 Lam Tan Hao +6 more
doaj +1 more source
Bio-Medical Library Bulletin, No. 109 (1992-04)
, 1992 Bio-Medical Library. (1992). Bio-Medical Library Bulletin, No. 109 (1992-04).
Bio-Medical Library
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source