Results 251 to 260 of about 6,578 (291)

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Effect of canal blocking on biodiversity of degraded peatlands: Insight from West Kalimantan. [PDF]

PLoS One
Imron MA, Rachmawati FD, Dewi T, Albihad D, Simanullang GMI, Poor EE.   +5 more
europepmc   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

The growing methodological toolkit for identifying and studying social learning and culture in non-human animals. [PDF]

Philos Trans R Soc Lond B Biol Sci
Whiten A, Rutz C.
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Bio-Inspired Metaheuristics for Time-Optimal Trajectory Planning in Cooperative Dual-Arm Bimanipulation. [PDF]

Biomimetics (Basel)
Peñacoba-Yagüe M, Sierra-García JE, Santos-Peñas M.   +2 more
europepmc   +1 more source

Bioinspired Hierarchical Architecture with Water Transport Channels for Strong Adhesion at the Sweating Interface

Advanced Science, EarlyView.
To address adhesion failure in sweaty epidermal electronics, this study proposes a cross‐species, multi‐scale biomimetic interface. By modeling staged wet adhesion, it integrates self‐regulating liquid bridges with directional drainage. This design ensures stable, high‐performance flexible sensing in complex physiological environments, offering a ...
Jieliang Zhao, Yu Xiang, Heng Wang, Huiqing Xu, Zhong Liu, Lulu Liang, Fengwen Jiang, Xuemei Chen, Wenzhong Wang, Chenqing Liu, Guodong Liu, Shaoze Yan, Xu Hou   +12 more
wiley   +1 more source

Family forest owner's perspectives on headwater streams in boreal forests: Motivations, values, and conservation actions. [PDF]

Ambio
Annala MJ, Lehtoranta V, Hilli A, Hokajärvi R, Kuoppala M, Mykrä H, Piirainen S.   +6 more
europepmc   +1 more source

Mental health tracking among young Russians: practices and motivations. [PDF]

Discov Ment Health
Paramonova A, Mikhaylova O.
europepmc   +1 more source

Valorization of waste pharmaceutical residues via pyrolysis: Simultaneous production of biochar for Cd2+ removal and high-quality bio-oil/syngas. [PDF]

PLoS One
Feng Z, Fu B, Han S, Yan H, Feng P, Li W, Qin T, Wang T, Zhang X, Jia J.   +9 more
europepmc   +1 more source