Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions
ABSTRACT Introduction There are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the ...
Siraj Mithoowani +2 more
wiley +1 more source
Quantitative source-oriented, bioaccumulation and toxicity of organic pollutants in a formerly mining area. [PDF]
Nechita C +5 more
europepmc +1 more source
Abstract Microbially derived geosmin causes an earthy off‐flavor in Atlantic salmon, Salmo salar, produced in land‐based systems, placing these products at risk for rejection. Therefore, a study was conducted to investigate the geosmin sensory threshold in market‐size Atlantic salmon.
John Davidson +4 more
wiley +1 more source
The Athabasca River regulates methylmercury burdens of waterbirds breeding downstream. [PDF]
Chételat J +15 more
europepmc +1 more source
Abstract Mercury (Hg) photoreduction on urban aerosols plays a critical role in atmospheric Hg cycling, yet the effects of the adsorption state on its kinetics and isotopic fractionation remain poorly constrained. This study investigates Hg(II) photoreduction under equilibrium (EAC) and non‐equilibrium adsorption conditions (NAC) using a flow‐through ...
Qiang Huang +4 more
wiley +1 more source
Engineering Fluoroacetate Dehalogenase by Growth‐Based Selections on Non‐Natural Organofluorides
We present a high‐throughput selection system to engineer fluoroacetate dehalogenases (FAcDs). By challenging E. coli populations that produce diverse FAcD libraries to grow on non‐natural organofluorides as their sole carbon source, we isolated a panel of FAcD variants with improved activity and altered substrate specificity.
Suzanne C. Jansen +2 more
wiley +2 more sources
G.AI.A: An Integrated Machine-Learning Platform for Predicting Bioaccumulation and Ecotoxicity of Pharmaceuticals. [PDF]
Tsoukas E +7 more
europepmc +1 more source
Risk Assessment of Bioaccumulation Substances. Part I: A Literature Review [PDF]
Karman, C.C., Tamis, J.E., Vries, P., de
core +1 more source
Large declines in organofluorine contamination indicated by subarctic marine mammal tissues. [PDF]
Sun JM +7 more
europepmc +1 more source
Bioaccumulation Exceedances by Pregnancy Contraindicated Neuropharmaceuticals during Development of Brown Trout in the Field. [PDF]
Grabicová K +4 more
europepmc +1 more source

