Results 41 to 50 of about 1,302,906 (282)

Chemical constituents isolated from the aerial parts of Helleborus cyclophyllus (A. Braun) Boiss. (Ranunculaceae), evaluation of their antioxidant and anti-inflammatory activity in vitro and virtual screening of molecular properties and bioactivity score

Natural Product Research, 2022
Chemical investigation of ethyl acetate extract from the aerial parts of Helleborus cyclophyllus (A.Braun) Boiss. led to the isolation of ten natural products, and their structures were identified to be: 2-deoxy-D-ribono-1,4-lactone (1), 2-O-feruloyl-L-malate (2), three flavonoids: quercetin 3-O-β-D-galactopyranoside (3), quercetin 3-O-6′′-(3-hydroxy-3-
Olga St, Tsiftsoglou, Michalis K, Stefanakis, Eirini N, Kalpourtzi, Dimitra I, Hadjipavlou-Litina, Diamanto M, Lazari   +4 more
openaire   +2 more sources

Influence of Brassica spp. rapeseed and canola meal, and supplementation of bioactive compound (AITC) on growth performance, intestinal-permeability, oocyst shedding, lesion score, histomorphology, and gene expression of broilers challenged with E. maxima

Poultry Science, 2022
This study was performed to investigate the effect of feeding Brassica spp. including full-fat rapeseed, canola meal, and allyl isothiocyanate (AITC) to broiler chicken challenged with E. maxima. A total of 576 one-day old male broiler chicks were completely randomized to 8 treatments with 6 replicated cages and 12 birds per cage.
S. Yadav, P.-Y. Teng, A.K. Singh, J. Choi, W.K. Kim   +4 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sex differences in Cognitive Abilities Test scores: a UK national picture [PDF]

, 2006
Background and aims. There is uncertainty about the extent or even existence of sex differences in the mean and variability of reasoning test scores ( Jensen, 1998; Lynn, 1994, ; Mackintosh, 1996).
Deary, Ian J., Smith, Pauline, Strand, Steve   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

NaPLeS: a natural products likeness scorer—web application and database

Journal of Cheminformatics, 2019
Natural products (NPs), often also referred to as secondary metabolites, are small molecules synthesised by living organisms. Natural products are of interest due to their bioactivity and in this context as starting points for the development of drugs ...
Maria Sorokina, Christoph Steinbeck
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Effects of Prior Knowledge and Lesson Outline on Note Taking and Test Scores [PDF]

, 2010
This study sought to find the effects of two teaching strategies—the use of lesson outline and the activation of prior knowledge—on note taking and test scores. The relationship between notes and test scores was also determined.
Lusung-Oyzon, Maria Vanessa P., Olmos, Oscar L.   +1 more
core  

Structural, spectral and bioactivity scores of 5,6 Dimethyl 1-H benzotriazole monohydrate: experimental and DFT study

International Journal of Biosciences (IJB), 2019
Bioactive molecules are chemical molecules which produced by living organism that exert a biological effect on other organisms. Benzotriazole derivatives are nitrogen containing bicyclic ring structure and have been confirmed for many biological activities, such as antibacterial, antifungal, anticancer, anti-inflammatory, analgesic, antimalarial and ...
openaire   +1 more source