Results 51 to 60 of about 21,527 (243)

Steroidal glycoalkaloids from Solanum nigrum target cytoskeletal proteins: an in silico analysis [PDF]

PeerJ, 2019
Background Solanum nigrum (black nightshade; S. nigrum), a member of family Solanaceae, has been endowed with a heterogeneous array of secondary metabolites of which the steroidal glycoalkaloids (SGAs) and steroidal saponins (SS) have vast potential to ...
Rumana Ahmad
doaj   +2 more sources

The FAR2CT formula: A novel scoring system for evaluating functional food efficacy from bioactive potential to clinical relevance

Journal of Functional Foods
The rapid growth of functional foods and nutraceuticals has outpaced the development of standardized tools to evaluate their efficacy and clinical relevance. To address this gap, we propose the Fahrul–Antonello–Raymond Assessment for Clinical Translation (FAR2CT) formula, a novel scoring system that integrates bioactive potential (P), preclinical ...
Tjandrawinata, Raymond Rubianto, Santini, Antonello, Nurkolis, Fahrul   +2 more
openaire   +2 more sources

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

A pharmacophore-guided deep learning approach for bioactive molecular generation

Nature Communications, 2023
The rational design of novel molecules with the desired bioactivity is a critical but challenging task in drug discovery, especially when treating a novel target family or understudied targets. We propose a Pharmacophore-Guided deep learning approach for
Huimin Zhu, Renyi Zhou, Dongsheng Cao, Jing Tang, Min Li   +4 more
doaj   +1 more source

Bioinspired Co‐Assembly Enables Multiscale Architected Hydrogels for 3D Printing With Integrated Antibacterial and Bioactive Functions

Advanced Functional Materials, EarlyView.
A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov, Francesca Netti, Sigal Rencus‐Lazar, Moran Aviv, Lihi Adler‐Abramovich   +4 more
wiley   +1 more source

Characterization of Antimicrobial, Antioxidant, and Leishmanicidal Activities of Schiff Base Derivatives of 4-Aminoantipyrine

Molecules, 2019
Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance.
Rommy Teran, Rommel Guevara, Jessica Mora, Lizeth Dobronski, Olalla Barreiro-Costa, Timo Beske, Jorge Pérez-Barrera, Ramiro Araya-Maturana, Patricio Rojas-Silva, Ana Poveda, Jorge Heredia-Moya   +10 more
doaj   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source

An integrative framework for prioritizing high-risk chemicals in children and adolescents: elevated blood pressure as a proof-of-concept

npj Emerging Contaminants
Environmental chemical mixtures pose a major challenge for outcome-specific chemical prioritization, particularly in vulnerable populations. Here, we analyzed serum levels of 97 chemicals in 1179 children and adolescents and developed a multidimensional ...
Ming Li, Lipan Wang, Mingye Zhang, Shiyu Shi, Zhixian Lv, Yun Tao, Jiawei Kang, Bin Zhou, Liqin Hu, Lulu Song, Youjie Wang, Surong Mei   +11 more
doaj   +1 more source

Computational identification of potential dengue RdRp inhibitors through docking, ADMET, and molecular dynamics

In Silico Research in Biomedicine
Dengue fever, caused by the dengue virus (DENV), remains a significant global health threat due to the lack of specific antiviral treatments or vaccines.
Hari Priya Narra, Venkata Monika Sarvani Atmakuri, Geethanjali Mandalapu, Shraddha Bhaskarani, Jyotsna Bandi, Garlapati Sujitha, Sudheer Kumar Katari, Anand Kumar Nelapati   +7 more
doaj   +1 more source

Computational Evaluation of ADMET Properties and Bioactive Score of Compounds from Encephalartos ferox [PDF]

Pharmacognosy Journal, 2020
Tsolanku Sidney Maliehe, Phakamani Hopewell Tsilo, Jabulani Siyabonga Shandu   +2 more
openaire   +1 more source