Results 211 to 220 of about 140,942 (311)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

open access: yesBrain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga   +11 more
wiley   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

open access: yesBrain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña   +20 more
wiley   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli   +8 more
wiley   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira   +3 more
wiley   +1 more source

A Non-Inferiority Evaluation of YAHE 4.0, an Alphacypermethrin-PBO Insecticide-Treated Net Against Pyrethroid Resistant Anopheles arabiensis in Experimental Huts in Moshi, North-Eastern Tanzania. [PDF]

open access: yesTrop Med Infect Dis
Matowo J   +20 more
europepmc   +1 more source

Development and Reproduction of Nesidiocoris tenuis Reuter (Heteroptera: Miridae): The Effect of Temperature, Origin and Food

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
Nymphal development took longer at 25°C than 30°C, and the Greek N. tenuis population developed more slowly than the commercial population. Nymphs clearly preferred E. kuehniella eggs over Artemia sp. cysts when both were offered equally. Egg production increased at 30°C, while female longevity declined.
Eleni Yiacoumi   +5 more
wiley   +1 more source

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