Results 91 to 100 of about 803,201 (379)

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Pharmacokinetics of single‐dose rivaroxaban under fed state in obese vs. non‐obese subjects: An open‐label controlled clinical trial (RIVOBESE‐PK)

Clinical and Translational Science
The evidence of rivaroxaban's pharmacokinetics in obese compared with non‐obese populations remains inconclusive. We aimed to compare the pharmacokinetic profile of rivaroxaban between obese and non‐obese populations under fed state. Participants who met
Majdoleen Alalawneh, Ahmed Awaisu, Ibtihal Abdallah, Hazem Elewa, Mohammed Danjuma, Kamal M. Matar, Akram M. ElKashlan, Yasser Elshayep, Fathy Ibrahim, Ousama Rachid   +9 more
doaj   +1 more source

Evaluating the potential health risk of organochlorine pesticides in selected protein foods from Abeokuta southwestern Nigeria

Environmental Pollutants & Bioavailability, 2020
This study evaluated the potential health risk of OCPs in selected protein foods. A total of 66 food samples were collected from selected areas in Abeokuta, southwestern Nigeria. Food samples were analyzed for OCPs using the standard method.
Adewale Matthew Taiwo, Oluseye Philip Talabi, Abdulahi Akingbolahan Akintola, Ezekiel Tosin Babatunde, Moarufat Olajumoke Olanrewaju, Boluwatife Helen Adegbaju, Samson Lekan Odebo, Aishat Ajoke Bello, Oluwatosin Fatimah Matti, Adeniran Anthony Adesanya, Sakinat Mojisola Ahmad   +10 more
doaj   +1 more source

Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. [PDF]

, 2019
PURPOSE:The purpose of this study was to determine the impact of food on gastric pH and the ability of over the counter betaine hydrochloride (BHCl) acid to reacidify gastric pH after food-induced elevations in gastric pH.
Benet, Leslie Z, Frassetto, Lynda A, Surofchy, Dalga D   +2 more
core  

Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]

, 2019
Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe, De Saeger, Sarah, Li, Yanshen, Li, Yi, Rao, Zhenghua, Sun, Feifei, Tan, Haiguang, Yang, Shupeng, Zhang, Huiyan, Zhou, Jinhui   +9 more
core   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Stream order and connectivity affect phosphorus distribution in plain river network

Environmental Pollutants & Bioavailability, 2020
The order and connectivity of streams influence phosphorus distribution extensively. In this work, the space-and-time variabilities of total phosphorus (TP), particulate phosphorus (PP), total dissolved phosphorus (TDP), dissolved reactive phosphorus ...
Huihua Lyu, Feng Zhou, Na Li
doaj   +1 more source

Bioavailability and bioaccessibility of food bioactive compounds; overview and assessment by in vitro methods.

Comprehensive Reviews in Food Science and Food Safety, 2020
Oral bioavailability is the key to the bioefficiency of food bioactive ingredients; it evaluates the relationship between foods and their health benefits.
C. Dima, E. Assadpour, S. Dima, S. Jafari   +3 more
semanticscholar   +1 more source

Low-level seaweed supplementation improves iodine status in iodine-insufficient women [PDF]

, 2014
Iodine insufficiency is now a prominent issue in the UK and other European countries due to low intakes of dairy products and seafood (especially where iodine fortification is not in place).
Combet, Emilie, Cousins, Frances, Lean, Michael E. J., Ma, Zheng Feei, Thompson, Brett   +4 more
core   +2 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source