Results 161 to 170 of about 991,955 (291)

Nanoparticle Drug Delivery System for Bioavailability Enchancement [PDF]

Nanoparticle-based drug delivery systems have revolutionized the field of pharmaceutical sciences by providing a promising approach to enhance the bioavailability of poorly soluble drugs.
Mansi Kailas Patil
core   +1 more source

Plant Flavonoid-Enriched Functional Foods for Polycystic Ovary Syndrome: Dietary Sources, Bioavailability Enhancement, and Personalized Intervention Strategies. [PDF]

Food Sci Nutr
Wang J, Zhu H, Shen Q, Zhong Y, Du Y, Yu W, Mao F, Yao Z, Zhu W, Sun L, Lin Q, Xu X, Zhu J.   +12 more
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Oral Bioavailability Enhancement of Melanin Concentrating Hormone, Development and In Vitro Pharmaceutical Assessment of Novel Delivery Systems. [PDF]

Pharmaceutics, 2021
Kósa D, Pető Á, Fenyvesi F, Váradi J, Vecsernyés M, Budai I, Németh J, Fehér P, Bácskay I, Ujhelyi Z.   +9 more
europepmc   +1 more source

HUMAN ENHANCEMENT

, 2009
Acknowledgements -- Introduction -- Human enhancement ethics: the state of the debate / Nick Bostrom and Julian Savulescu -- Pt. I. Human enhancement in general -- 1. Can anyone really be talking about ethically modifying human nature?

core  

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Dietary (-)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health. [PDF]

Nutrients
Niu L, Luo Y, Xie W, Wang C, Liu Z.
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Crystal Engineering as an Efficient Medicinal Chemistry Tool for Animal PK Bioavailability Enhancement in Early Pre-Clinical Research. [PDF]

Pharmaceuticals (Basel)
Becker A, von Essen C, Burgdorf L, Lecomte M, Bischof D.   +4 more
europepmc   +1 more source

Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection. [PDF]

Molecules, 2022
Li J, Chen G, Meng Z, Wu Z, Gan H, Zhu X, Han P, Liu T, Wang F, Gu R, Dou G.   +10 more
europepmc   +1 more source