A novel approach to improving solubility of drugs: chelation-assisted solubility enhancement (CHASE) [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryWe explore a novel concept of metal Chelation-assisted Solubility Enhancement (CHASE). This study is based on complexation with Na+ or K+. A series of 6 compounds are studied by conjugating a hydrophobic moiety with benzo-15-crown-5.
TanPhat Nguyen +3 more
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Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability
Pharmaceutics, 2023 (1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)—a new anticoagulation drug—has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10−6 cm/s across
Juseung Lee +7 more
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Preparation of Hydrochlorothiazide Nanoparticles for Solubility Enhancement [PDF]
Molecules, 2016 Nanoparticles can be considered as a useful tool for improving properties of poorly soluble active ingredients. Hydrochlorothiazide (Class IV of the Biopharmaceutical Classification System) was chosen as a model compound.
Eliska Vaculikova +7 more
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A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2020 A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release
Avinash Ramrao Tekade +1 more
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Technologies for Solubility, Dissolution and Permeation Enhancement of Natural Compounds
Pharmaceuticals, 2022 The current review is based on the advancements in the field of natural therapeutic agents which could be utilized for a variety of biomedical applications and against various diseases and ailments.
Meshal Alshamrani +4 more
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Optimization of ivacaftor-loaded solid lipid nanoparticles for solubility enhancement [PDF]
Frontiers in PharmacologyBackgroundCystic fibrosis (CF) is a systemic disease which primarily affects pulmonary system, but also extends to different important organs to cause multitude of associated diseases, leading to rise in rate of morbidity and mortality.
Akshay Parihar +5 more
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Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds [PDF]
ADMET and DMPK, 2020 Christel Bergström, Antonio Llinàs
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Scanning Sildenafil Citrate Solubility in Hydrotropic Solutions [PDF]
المجلة العراقية للصيدلة, 2023 Background: Sildenafil citrate (SC) is a selective phosphodiesterase-5 inhibitor with low aqueous solubility (4.1 mg/mL in water), resulting in only 40% bioavailability after oral administration. SC is classified as class II by the Biopharmaceutical Drug
Ebtissam Al-dulaimi +2 more
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A Review of Coformer Utilization in Multicomponent Crystal Formation
Molecules, 2022 Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness.
Nasrul Wathoni +4 more
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Crystals, 2023 Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are toxic and carcinogenic compounds widely present in the natural environment, posing a serious threat to the environment and human health. However, the removal of OPAHs is mainly hindered by their low
Yue Niu +6 more
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