Preparation of Hydrochlorothiazide Nanoparticles for Solubility Enhancement [PDF]
Molecules, 2016 Nanoparticles can be considered as a useful tool for improving properties of poorly soluble active ingredients. Hydrochlorothiazide (Class IV of the Biopharmaceutical Classification System) was chosen as a model compound.
Eliska Vaculikova +7 more
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Development of a quaternary ammonium poly (amidoamine) dendrimer-based drug carrier for the solubility enhancement and sustained release of furosemide [PDF]
Frontiers in Chemistry, 2023 Furosemide (FRSD) is a loop diuretic that has been categorized as a class IV drug according to the Biopharmaceutics Classification System (BCS). It is used in the treatment of congestive heart failure and edema.
E. Murugan, V. Yogaraj
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A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs [PDF]
Advanced Pharmaceutical Bulletin, 2020 A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release
Avinash Ramrao Tekade +1 more
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Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds [PDF]
ADMET and DMPK, 2020 Christel Bergström, Antonio Llinàs
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Erratum: Development of a quaternary ammonium poly (amidoamine) dendrimer-based drug carrier for the solubility enhancement and sustained release of furosemide [PDF]
Frontiers in Chemistry, 2023 Frontiers Production Office
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A Review of Coformer Utilization in Multicomponent Crystal Formation
Molecules, 2022 Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness.
Nasrul Wathoni +4 more
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Crystals, 2023 Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are toxic and carcinogenic compounds widely present in the natural environment, posing a serious threat to the environment and human health. However, the removal of OPAHs is mainly hindered by their low
Yue Niu +6 more
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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
Pharmaceuticals, 2021 One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor ...
Bharti Gupta +4 more
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Polytechnic Journal, 2021 Drugs which fall into Class II of Biopharmaceutical Classification System suffer from poor aqueous solubility that limits the dissolution and oral bioavailability.
Hemn L. Qader +2 more
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Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability
Pharmaceutics, 2023 (1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)—a new anticoagulation drug—has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10−6 cm/s across
Juseung Lee +7 more
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