Enhancement of Solubility of Diclofenac Sodium by Pastillation Method [PDF]
, 2021 The Diclofenac Sodium is BCS class II drug which comes under the antipyretic class drug, and has a wide range of use. But due to its low solubility it has low dissolution rate and hence reduced bioavailability.
Warokar, Amol +3 more
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An evaluation of thermodynamic models for the prediction of drug and drug-like molecule solubility in organic solvents [PDF]
, 2011 Prediction of solubility of active pharmaceutical ingredients (API) in different solvents is one of the main issue for crystallization process design. Experimental determination is not always possible because of the small amount of product available in ...
Béatrice Biscans +5 more
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An overview of techniques for multifold enhancement in solubility of poorly soluble drugs
Current Issues in Pharmacy and Medical Sciences, 2019 Poor water solubility of newly discovered compounds has become the most common challenge in the drug development process. Indeed, poor solubility is considered as the root cause of failure of drug during drug development phases.
Ansari Mohammad Javed
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SOLUBILITY ENHANCEMENT METHODS WITH IMPORTANCE OF HYDROTROPY [PDF]
, 2012 The effectiveness of formulation depends particularly on how efficiently is drug available at the site of action. Therapeutic effectiveness of a drug basically depends upon bioavailability and the solubility of drug moiety.
ali, Md. Sajid, Choudhary, Vicky
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The Development of Transdermal Piroxicam Using HPMC Matrices With PVP K-30 as a Penetration Enhancer [PDF]
, 2006 The physicochemical properties such as solubility, partition coefficient, and membrane permeability of a drug are required for formulating and estimating drugs absorption that pass through biological membranes.
Aryani, Ni Luh Dewi
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Enhancement of solubility of paclitaxel by applying factorial design
Current Medicine Research and Practice, 2021 Background: The poor aqueous solubility and low bioavailability of antineoplastic drugs restrict the oral route for the cancer therapy. However, specific nanotechnologies developed to address this issue.
Pragya Baghel +4 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Solubility enhancement of simvastatin for wound dressing preparation. [PDF]
Journal of Advanced Biomedical and Pharmaceutical SciencesSimvastatin (SMV) is a well-known antihyperlipidemic drug that has demonstrated wound healing effects. However, its clinical application is hindered by poor solubility.
Amal K. Hussein +3 more
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Solubility enhancement of nimodipine using mixed hydrotropic solid dispersion technique
Zanco Journal of Medical Sciences, 2020 Background and objective: Low aqueous solubility of active pharmaceutical ingredients has an effect on both formulation development and bioavailability.
Naz Jamal Ibrahim +3 more
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Life, 2023 A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market.
Lakshmi Kumari +7 more
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