Results 11 to 20 of about 1,040,538 (251)
Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
Pharmaceuticals, 2021 One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor ...
Bharti Gupta +4 more
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Micronization Techniques for Solubility Enhancement of Aceclofenac as a potential Solubility Enhancement Approach [PDF]
, 2023 Aceclofenac is a BCS class II poorly aqueous soluble drug that has significant oral bioavailability limitations after intake. Numerous solubility enhancement techniques are available for the solubility enhancement, out of various techniques Micronization
Vishal Gupta +2 more
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Computing the aqueous solubility of organic drug-like molecules and understanding hydrophobicity [PDF]
, 2015 This thesis covers a range of methodologies to provide an account of the current (2010-2014) state of the art and to develop new methods for solubility prediction.
McDonagh, James L.
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Crystals, 2022 The most favored approach for drug administration is the oral route. Several anticancer drugs come under this category and mostly lack solubility and oral bioavailability, which are the most common causes of inadequate clinical efficiency. Enhancing oral
Divya Dhatri Kara, Mahalaxmi Rathnanand
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Preparation and optimization of microemulsion of rosuvastatin calcium
Journal of Pharmacy and Bioallied Sciences, 2012 Due to very less bioavailability (20%) of Rosuvastatin calcium, an attempt was made to develop and optimize microemulsion formulation. Capmul MCM, Tween 20 and PEG 400 were selected as oil, surfactant and cosurfactant respectively as the drug is having ...
B Zalak Patel +3 more
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Beni-Suef University Journal of Basic and Applied Sciences, 2015 Rilpivirine (RPV) is a pharmaceutical drug used for the treatment of HIV infection. The drug is characterized with poor aqueous solubility and dissolution rate leading to low bioavailability of the drug.
Pavan kommavarapu +3 more
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Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]
, 2006 The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
Davies, David B. +3 more
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Pharmaceutics, 2023 Since its introduction to the market in the 1970s, ketoprofen has been widely used due to its high efficacy in moderate pain management. However, its poor solubility and ulcer side effects have diminished its popularity.
Heba A. Abou-Taleb +4 more
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Investigation of Solubility Enhancement Approaches of Ticagrelor
Iraqi Journal of Pharmaceutical Sciences, 2018 Ticagrelor is an orally administered antiplatelet medicine, direct-acting P2Y12-receptor antagonist. Ticagrelor binds reversibly and noncompetitively to the P2Y12 receptor at a site distinct from that of the endogenous agonist adenosine diphosphate (ADP).
Ihsan A. Mohammed, Mowafaq M. Ghareeb
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Solubility and Bioavailability Enhancement of Oridonin: A Review
Molecules, 2020 Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects.
Yuanyuan Zhang +5 more
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