Results 11 to 20 of about 203,317 (299)
Drug Solubility: Importance and Enhancement Techniques [PDF]
ISRN Pharmaceutics, 2012 Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities ...
Savjani, Ketan T. +2 more
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Solubility Enhancement of Poorly Water Soluble Drug
, 2023 The Biopharmaceutical Classification System includes solubility as one of its core criteria, and dissolution rate is the most crucial variable affecting a drug's bioavailability. A weakly water-soluble medication is defined as a substance with a solubility of less than 1 part per 10,000 parts of water.
Madkaikar, S.A., Shukla, U.D.
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Crystals, 2022 The most favored approach for drug administration is the oral route. Several anticancer drugs come under this category and mostly lack solubility and oral bioavailability, which are the most common causes of inadequate clinical efficiency. Enhancing oral
Divya Dhatri Kara, Mahalaxmi Rathnanand
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Enhanced neuroinvasion by smaller, soluble prions [PDF]
Acta Neuropathologica Communications, 2017 Infectious prion aggregates can propagate from extraneural sites into the brain with remarkable efficiency, likely transported via peripheral nerves. Yet not all prions spread into the brain, and the physical properties of a prion that is capable of transit within neurons remain unclear. We hypothesized that small, diffusible aggregates spread into the
Bett, Cyrus +9 more
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Preparation and optimization of microemulsion of rosuvastatin calcium
Journal of Pharmacy and Bioallied Sciences, 2012 Due to very less bioavailability (20%) of Rosuvastatin calcium, an attempt was made to develop and optimize microemulsion formulation. Capmul MCM, Tween 20 and PEG 400 were selected as oil, surfactant and cosurfactant respectively as the drug is having ...
B Zalak Patel +3 more
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Pharmaceutics, 2023 Since its introduction to the market in the 1970s, ketoprofen has been widely used due to its high efficacy in moderate pain management. However, its poor solubility and ulcer side effects have diminished its popularity.
Heba A. Abou-Taleb +4 more
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Solubility Interactions in Compensated, Heavily Doped Germanium [PDF]
, 1965 The solubility of the two donors, arsenic and antimony, in Ge at 870°C was enhanced by the acceptor dopant Ga at concentrations ≥ 10^19 cm^–3. The observed enhancement is in agreement with theory of the dopant-carrier ionization equilibrium in the ...
McCaldin, J. O.
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Beni-Suef University Journal of Basic and Applied Sciences, 2015 Rilpivirine (RPV) is a pharmaceutical drug used for the treatment of HIV infection. The drug is characterized with poor aqueous solubility and dissolution rate leading to low bioavailability of the drug.
Pavan kommavarapu +3 more
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Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
Biomedicines, 2022 The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with
Dixit V. Bhalani +3 more
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Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]
, 2011 Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar +153 more
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