Results 41 to 50 of about 203,317 (299)
Protein solubility and folding enhancement by interaction with RNA. [PDF]
PLoS ONE, 2008 While basic mechanisms of several major molecular chaperones are well understood, this machinery has been known to be involved in folding of only limited number of proteins inside the cells. Here, we report a chaperone type of protein folding facilitated
Seong Il Choi +12 more
doaj +1 more source
Complexation and enhancement of temozolomide solubility with cyclodextrins
Brazilian Journal of Pharmaceutical Sciences, 2018 Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form ...
Berna Gürten +3 more
doaj +1 more source
Polymers Enhance Chlortetracycline Hydrochloride Solubility
International Journal of Molecular SciencesChlortetracycline hydrochloride (CTC) is a broad-spectrum tetracycline antibiotic with a wide range of antibacterial activities. Due to low solubility, poor stability, and low bioavailability, clinical preparation development is limited. We sought to improve these solubility and dissolution rates by preparing solid dispersions.
Chao Zhang +5 more
openaire +2 more sources
Gels, 2022 In this study, we report the highly responsive chitosan-based chemically cross-linked nanomatrices, a nano-version of hydrogels developed through modified polymerization reaction for solubility improvement of poorly soluble drug simvastatin.
Anam Saleem +5 more
doaj +1 more source
Design and in Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin [PDF]
, 2013 Curcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties.
El-Sherbiny, Ibrahim M. +3 more
core +2 more sources
Solubility enhancement and solid-state characterisation [PDF]
Pharmaceutical Development and Technology, 2018 The concept of “molecular inflation”1, where the molecular weight of patented and marketed drugs is increasing (as is their molecular complexity), is now demonstrated to be a reality.
openaire +2 more sources
PharmaceuticsBackground/Objectives: Fenbendazole is a potential cancer treatment and a proven antiparasitic in veterinary applications. However, its poor water solubility limits its application.
Amirhossein Karimi +6 more
doaj +1 more source
The enhancement of the aqueous solubility of ritonavir via formulation of a drug-phospholipid complex [PDF]
, 2015 Objective: To evaluate the enhancement of aqueous solubility of a poorly water soluble drug ritonavir by forming its complex with a phospholipid (Phospholipon®90H)
Bernardez, M. +6 more
core +1 more source
Solubility Enhancement of Poorly Water-Soluble Drugs
International Journal of Advanced Research in Science, Communication and TechnologyThis article provides an overview of nanocrystals as a potentially valuable technology for enhancing the solubility of water-insoluble pharmaceuticals. Nanocrystals increase surface area by reducing particle size, hence improving bioavailability and solubility.
null Mr. Sufiyan Ahemad Abdul Mukthar +1 more
openaire +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior +7 more
wiley +1 more source