Results 41 to 50 of about 1,040,538 (251)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Minor effect of physical size sorting on iron solubility of transported mineral dust [PDF]

, 2011
Observations show that the fractional solubility of Fe (FS-Fe, ratio of dissolved to total Fe) in dust aerosol increases dramatically from ~0.1% in regions of high dust mass concentration to 80% in remote regions where concentrations are low.
G. Fones, Drake, N, N. Drake, Fones, G., Brooks, B., Carslaw, KS, Jickells, T. D., Drake, N., Krom, MD, Fones, Gary, Jickells, TD, G. W. Mann, B. Brooks, Mann, GW, Brooks, B, Benning, L. G., Woodhouse, M. T., Baker, AR, G. R. Fones, Shi, Z. B., Baker, A. R., Carslaw, K. S., Z. B. Shi, M. D. Krom, L. G. Benning, Savov, I, T. D. Jickells, Shi, Zongbo; id_orcid, Krom, M. D., K. S. Carslaw, Benning, LG, Fones, G. R., A. R. Baker, Woodhouse, M. T, Savov, I., M. T. Woodhouse, Mann, G. W., Fones, GR, I. Savov, Woodhouse, MT   +39 more
core   +2 more sources

Investigation of Fenbendazole Solubility Using Particle Size Reduction Methods in the Presence of Soluplus^®

Pharmaceutics
Background/Objectives: Fenbendazole is a potential cancer treatment and a proven antiparasitic in veterinary applications. However, its poor water solubility limits its application.
Amirhossein Karimi, Pedro Barea, Óscar Benito-Román, Beatriz Blanco, María Teresa Sanz, Clement L. Higginbotham, John G. Lyons   +6 more
doaj   +1 more source

Complexation and enhancement of temozolomide solubility with cyclodextrins

Brazilian Journal of Pharmaceutical Sciences, 2018
Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form ...
Berna Gürten, Elçin Yenigül, Ali Demir Sezer, Seyda Malta   +3 more
doaj   +1 more source

Protein solubility and folding enhancement by interaction with RNA. [PDF]

PLoS ONE, 2008
While basic mechanisms of several major molecular chaperones are well understood, this machinery has been known to be involved in folding of only limited number of proteins inside the cells. Here, we report a chaperone type of protein folding facilitated
Seong Il Choi, Kyoung Sim Han, Chul Woo Kim, Ki-Sun Ryu, Byung Hee Kim, Kyun-Hwan Kim, Seo-Il Kim, Tae Hyun Kang, Hang-Cheol Shin, Keo-Heun Lim, Hyo Kyung Kim, Jeong-Min Hyun, Baik L Seong   +12 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Characterization of the conglomerate form of acetyl-dl-leucine by thermal analysis and solubility measurements [PDF]

, 2012
Starting from a mixture of enantiomers in solution, crystallization can generate different types of crystals. In order to determine which type of crystal is obtained in the case of acetylleucine, an active pharmaceutical ingredient (API), analytical ...
B. Biscans, Pena, Richard, S. Teychené, Estime, Nicolas, Biscans, Béatrice, R. Pena, N. Estime, Teychené, Sébastien, Autret, Jean Marie, J.M. Autret   +9 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source