Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics
Biomedicines, 2022 The low water solubility of pharmacoactive molecules limits their pharmacological potential, but the solubility parameter cannot compromise, and so different approaches are employed to enhance their bioavailability. Pharmaceutically active molecules with
Dixit V. Bhalani +3 more
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Decision trees to characterise the roles of permeability and solubility on the prediction of oral absorption. [PDF]
, 2015 Oral absorption depends on many physiological, physiochemical and formulation factors. Two important properties that govern oral absorption are in vitro permeability and solubility, which are commonly used as indicators of human intestinal absorption ...
Newby, Danielle +6 more
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FORMULATION AND CHARACTERIZATION OF THERMOSENSITIVE CHITOSAN HYDROGEL LOADED WITH ERLOTINIB: FULL FACTORIAL DESIGN OF RELEASE DATA [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2023 Erlotinib is a Tyrosine Kinase Inhibitor (TKI) that is utilized in the treatment of various types of tumors expressing the epidermal growth factor receptors (EGFR) protein.
Shaaban Osman +2 more
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Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API) [PDF]
, 2010 Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).
Estime, Nicolas +3 more
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Structural Modification and Solubility Enhancement of Glutenin by pH-Shifting [PDF]
Shipin Kexue, 2023 Glutenin (Glu) was modified by pH-shifting to improve its properties. The effect of pH-shifting treatment on the structure and micromorphology of glutenin was investigated by dynamic light scattering (DLS), transmission electron microscopy (TEM ...
RONG Yujuan, HOU Yuwei, CAO Xiaoqian, ZHANG Jiajia, ZHOU Bin
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Uniting cheminformatics and chemical theory to predict the intrinsic aqueous solubility of crystalline druglike molecules [PDF]
, 2014 We present four models of solution free-energy prediction for druglike molecules utilizing cheminformatics descriptors and theoretically calculated thermodynamic values.
van Mourik, Tanja +17 more
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Water solubility in aluminosilicate melts of haplogranite composition at 2 kbar [PDF]
, 1992 The compositional dependence of H2O solubility was investigated at 2 kbar and 800°C in haplogranite melts (system SiO2---1bNaAlSi3O8---1bKAlSi3O8 or Qz---1bAb---1bOr).
Taylor, Richard P. +3 more
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The boehmite ‘solubility gap’ [PDF]
, 2010 Boehmite, rather than gibbsite, precipitation has been proposed in the literature as a potential energy-saving modification of the Bayer process for the production of alumina. Previous experimental studies have reported that true equilibrium solubilities
Erich Königsberger +5 more
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Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
Molecules, 2021 Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects.
Huili Shao +6 more
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Enhancement of Drug Solubility: Review Abstract Articles [PDF]
, 2018 Introduction: Poor water-solubility is a common characteristic of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, ...
Varshosaz, Jaleh, safaei, Sadaf
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