Investigation of Solubility Enhancement Approaches of Ticagrelor
Iraqi Journal of Pharmaceutical Sciences, 2018 Ticagrelor is an orally administered antiplatelet medicine, direct-acting P2Y12-receptor antagonist. Ticagrelor binds reversibly and noncompetitively to the P2Y12 receptor at a site distinct from that of the endogenous agonist adenosine diphosphate (ADP).
Ihsan A. Mohammed, Mowafaq M. Ghareeb
doaj +1 more source
The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri [PDF]
, 2016 In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed.
Bobde, Yamini S +6 more
core +2 more sources
Solubility and Bioavailability Enhancement of Oridonin: A Review
Molecules, 2020 Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects.
Yuanyuan Zhang +5 more
doaj +1 more source
The use of heat and chemical penetration enhancers to increase the follicular delivery of erythromycin to the skin [PDF]
, 2019 Copyright © 2019. Published by Elsevier B.V.The effect of heat on the follicular absorption of drugs into the skin has not previously been investigated.
Akomeah +42 more
core +2 more sources
ENHANCEMENT OF SOLUBILITY OF POORLY SOLUBLE DRUG LANSOPRAZOLE
International Journal of Applied Pharmaceutics, 2022 Objective: To improve the solubility of lansoprazole with solid dispersion (SD) method by using hydrophilic polymer PEG 6000, PEG 15000 and amphiphilic polymer solupus. Methods: Solid dispersions of lansoprazole were prepared with polymers PEG 6000, PEG 15000 and amphiphilic polymer soluplus, using three methods of preparation–1) solvent melting 2 ...
SWATI MUTHA +5 more
openaire +1 more source
Technologies for Solubility, Dissolution and Permeation Enhancement of Natural Compounds
Pharmaceuticals, 2022 The current review is based on the advancements in the field of natural therapeutic agents which could be utilized for a variety of biomedical applications and against various diseases and ailments.
Meshal Alshamrani +4 more
doaj +1 more source
How Soluble GARP Enhances TGFβ Activation
PLOS ONE, 2016 GARP (glycoprotein A repetitions predominant) is a cell surface receptor on regulatory T-lymphocytes, platelets, hepatic stellate cells and certain cancer cells. Its described function is the binding and accommodation of latent TGFβ (transforming growth factor), before the activation and release of the mature cytokine.
Fridrich, Sven +7 more
openaire +6 more sources
Novel Strategies for Solubility and Bioavailability Enhancement of Bufadienolides
Molecules, 2021 Toad venom contains a large number of bufadienolides, which have a variety of pharmacological activities, including antitumor, cardiovascular, anti-inflammatory, analgesic and immunomodulatory effects.
Huili Shao +6 more
doaj +1 more source
Ultrasound in gas–liquid systems: Effects on solubility and mass transfer [PDF]
, 2008 The effect of ultrasound on the pseudo-solubility of nitrogen in water and on gas–liquid mass transfer kinetics has been investigated in an autoclave reactor equipped with a gas induced impeller.
Andriantsiferana, Caroline +3 more
core +1 more source
Physical absorption of CO2 and propene into toluene/water emulsions [PDF]
, 1994 The physical absorption of CO2 and propene into toluene/water emulsions is studied in a stirred cell and laminar film absorber. Experimentally observed masstransfer rates are compared to an absorption model, based on Higbie's penetration theory ...
Littel, R.J. +3 more
core +3 more sources