Results 61 to 70 of about 1,040,538 (251)

SOLUBILITY ENHANCEMENT OF MODEL COMPOUNDS [PDF]

, 2017
Solubility is the amount of solute in the solvent system at phase equilibrium with certain temperature and pressure. Many of the new chemical entities are lipophilic molecules that require techniques to enhance solubility.
Pitani, Lavanya
core  

Triboelectrification and dissolution property enhancements of solid dispersions [PDF]

, 2015
The use of solid dispersion techniques to modify physicochemical properties and improve solubility and dissolution rate may result in alteration to electrostatic properties of particles.
Conway, Barbara R, Hiba Al-Hamidi (16203491), Šupuk, Enes, Conway, Barbara R., Kofi Asare-Addo (4172488), Al-Hamidi, Hiba, Owusu-Ware, Samuel, Asare-Addo, Kofi, Samuel Owusu-Ware (16228529), Barbara R. Conway (4172491), Enes Šupuk (16228532), Nokhodchi, Ali, Ali Nokhodchi (4465915)   +12 more
core   +1 more source

Design, optimization and evaluation of glipizide solid self-nanoemulsifying drug delivery for enhanced solubility and dissolution

Saudi Pharmaceutical Journal, 2015
A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was systematically optimized using a circumscribed central composite design by ...
Rajendra Narayan Dash, Habibuddin Mohammed, Touseef Humaira, Devi Ramesh   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The development of ternary and quaternary solid dispersion based hydrotropic blends of atorvastatin calcium

Zanco Journal of Medical Sciences
Background and objective: Atorvastatin calcium (ATV) has a solubility in aqueous solutions of greater than 0.1 mg/ml to less than 1 mg/ml, which is very slightly soluble.
Suren Azad Ramadhan, Huner K. Omer
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Molecular interactions, solubility, and cytotoxic activity of 4‑hydroxycoumarin in choline chloride‑based acidic deep eutectic solvents

Scientific Reports
This study systematically investigated the solubility enhancement of 4-hydroxycoumarin (4HC), a poorly water-soluble pharmaceutical compound, in three novel acidic deep eutectic solvents (ADESs) prepared from choline chloride (ChCl) and acidic hydrogen ...
Mohammad Khorsandi, Hemayat Shekaari, Masoumeh Mokhtarpour, Parisa Akbarzadeh Gondoghdi, Hamed Hamishehkar   +4 more
doaj   +1 more source

A Review on Solubility Enhancement of Antifungal Drugs

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Fungal infections pose a significant threat to immunocompromised individuals, yet the efficacy of antifungal therapies is often hindered by the poor aqueous solubility of many antifungal agents, particularly azoles. Enhancing solubility is essential for
Aymen Mohammed Baseet, Ghaidaa S. Hameed, Dalya Basil Hanna, Omar Sarheed   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source