Results 81 to 90 of about 203,317 (299)
Transdermal evaluation of caffeine in different formulations and excipients [PDF]
, 2013 Background: The stratum corneum(SC) forms adifficultphysical barrier fordrugs to pass through the skin. Several strategieswere developed to overcome this barrier.Optimization of topical drug formulations by selected excipients may facilitate the ...
Boonen, Jente +7 more
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Review on Solubility Enhancement of Antifungal Drugs
Al-Mustansiriyah Journal of Pharmaceutical SciencesFungal infections pose a significant threat to immunocompromised individuals, yet the efficacy of antifungal therapies is often hindered by the poor aqueous solubility of many antifungal agents, particularly azoles. Enhancing solubility is essential for
Aymen Mohammed Baseet +3 more
doaj +1 more source
Development of a high strength Al-Mg2Si-Mg-Zn based alloy for high pressure die casting [PDF]
, 2015 A high strength Al-Mg2Si-Mg-Zn based alloy has been developed for the application in high pressure die casting to provide improved mechanical properties.
Badal +22 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Kinetics of Carbon Dioxide with tertiary Amines in aqueous solution [PDF]
, 1999 The reaction of CO2 with TEA, DMMEA, and DEMEA has been studied at 293, 303, 318 and 333 K. All the kinetic experiments were carried out in a stirred cell reactor operated with a flat, smooth and horizontal gas-liquid interface. A numerical method, which
Littel, R.J. +2 more
core +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Single crystal growth and structural characterization of FeTe1-xSx
, 2010 We have synthesized single crystals of FeTe1-xSx and investigated the structural and physical properties. The actual S concentration was found to be significantly smaller than the starting nominal value.
Deguchi, Keita +6 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Modelling of simultaneous mass and heat transfer with chemical reaction using the Maxwell-Stefan theory I. Model development and isothermal study [PDF]
, 1995 A general applicable model has been developed which can predict mass and heat transfer fluxes through a vapour/gas-liquid interface in case a reversible chemical reaction with associated heat effect takes place in the liquid phase.
Frank, M.J.W. +4 more
core +4 more sources