Results 101 to 110 of about 203,317 (299)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Enhancing methyldopa solubility via green supercritical fluid techniques using ethanol co-solvent

Scientific Reports
The aim of this study is to investigate the solubility of methyldopa in supercritical carbon dioxide. Solubility was examined at temperatures of 338, 328, 318, and 308 K, in both the presence and absence of a co-solvent.
Hadil Faris Alotaibi, Suleiman Ibrahim Mohammad, Asokan Vasudevan, Suranjana V. Mayani, Suhas Ballal, Munthar Kadhim Abosaoda, Abhayveer Singh, Subhashree Ray, Atreyi Pramanik   +8 more
doaj   +1 more source

Comparative evaluation of ternary amorphous solid dispersions: Identifying optimal excipient systems for enhancing drug solubility

International Journal of Pharmaceutics: X
The limited aqueous solubility of numerous active pharmaceutical ingredients (APIs) remains a major barrier to achieving optimal oral bioavailability, therapeutic efficacy, and clinical translation.
Arif Budiman, Lisa Efriani Puluhulawa, Faradila Ratu Cindana Mo’o, Nurain Thomas, Melvern Theodorik S. Biu, Febrina Amelia Saputri, Siti Farah Rahmawati, Diah Lia Aulifa, Salma Amaliah, Agus Rusdin   +9 more
doaj   +1 more source

Ligand enhanced upconversion of near-infrared photons with nanocrystal light absorbers. [PDF]

, 2016
We designed and synthesized a tetracene derivative 4-(tetracen-5-yl)benzoic acid (CPT) as a transmitter ligand used in PbS/PbSe nanocrystal (NC) sensitized upconversion of near infrared (NIR) photons.
Huang, Zhiyuan, Li, Xin, Mahboub, Melika, Simpson, Duane E, Tang, Ming L   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Mechanically driven alloying and grain size changes in nanocrystalline Fe-Cu powders [PDF]

, 1993
Highly supersaturated nanocrystalline FexCu100-x alloys (10 less-than-or-equal-to x less-than-or-equal-to 95) have been prepared by mechanical alloying of elemental crystalline powders.
Eckert, J., Holzer, J. C., Johnson, W. L., Krill, C. E., III   +3 more
core  

Effect of 1 wt% LiF additive on the densification of nanocrystalline Y2O3 ceramics by spark plasma sintering [PDF]

, 2011
Densification of nanocrystalline cubic yttria (nc-Y2O3) powder, with 18 nm crystal size and 1 wt% LiF as a sintering additive was investigated. Specimens were fabricated by spark plasma sintering at 100 MPa, within the temperature range of 700–1500 °C ...
Chaim, Rachman, Chevallier, Geoffroy, Estournès, Claude, Marder, Rachel   +3 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Kinetics of CO2 with primary and secondary amines in aqueous solutions - I. Zwitterion deprotonation kinetics for DEA and DIPA in aqueous blends of alkanolamines [PDF]

, 1992
The deprotonation kinetics of the DEA—CO2 and the DIPA—CO2 zwitterions have been studied in aqueous blends of amines at 298 K. Amine mixtures investigated were: DEA—TEA, DEA—MDEA, DEA—DMMEA, DEA—DEMEA, DIPA—TEA. DIPA—MDEA, DIPA—DMMEA, DIPA—DEMEA.
Littel, R.J., Littel, R.J., van Swaaij, Willibrordus Petrus Maria, Versteeg, Geert   +3 more
core   +5 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source