Results 101 to 110 of about 1,040,538 (251)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Solubility enhancement factor for the herbicide-surfactant systems.

, 2013
Solubility enhancement factor for the herbicide-surfactant systems.
María del Carmen Galán-Jiménez (391369), Shlomo Nir (391371), Yael-Golda Mishael (391370), Esmeralda Morillo (306650), Tomás Undabeytia (309861)   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Solubility Enhancement of Rifapentine by Inclusion Complex [PDF]

, 2011
Solubility enhancement of poorly aqueous soluble drugs is an important aspect of formulation development. The objective of the study was to compare the aqueous solubility and dissolution characteristics of rifapentine enhanced by solid dispersion and ...
Pankaj Nainwal, Kapil Kalra, Manisha Gaur, , D.A. Jain, Ravindra P. Singh   +4 more
core  

Strategic action planning for ecological restoration partnerships: a guide prepared for the Oregon Watershed Enhancement Board

, 2023
in collaboration with Bonneville Environmental Foundation.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Polysorbate 80 – Modulated nanocrystallization for enhancement of griseofulvin solubility

German Journal of Pharmaceuticals and Biomaterials
Griseofulvin (GRFV1) is used in the treatment of many fungal infections, including ringworm and athlete’s foot, as well as fungal infections of the scalp, fingernails, and toenails. However, its bioavailability is limited by poor water solubility.
Emmanuel O. Olorunsola, Sifon Ekpeowo, Mumuni Momoh, Michael Adikwu   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Solubility Enhancement of Dihydroquercetin via "Green" Phase Modification. [PDF]

Int J Mol Sci, 2022
Terekhov RP, Ilyasov IR, Beloborodov VL, Zhevlakova AK, Pankov DI, Dzuban AV, Bogdanov AG, Davidovich GN, Shilov GV, Utenyshev AN, Saverina EA, Selivanova IA.   +11 more
europepmc   +1 more source