Results 121 to 130 of about 203,317 (299)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Solubility Enhancement of Dihydroquercetin via "Green" Phase Modification. [PDF]

Int J Mol Sci, 2022
Terekhov RP, Ilyasov IR, Beloborodov VL, Zhevlakova AK, Pankov DI, Dzuban AV, Bogdanov AG, Davidovich GN, Shilov GV, Utenyshev AN, Saverina EA, Selivanova IA.   +11 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A new model to correlate solubility of drug compounds in supercritical carbon dioxide

Chemical Thermodynamics and Thermal Analysis
A new solubility model based on enhancement factor concept is proposed to correlate solubility of drug compounds in supercritical carbon dioxide (SCCO2). The correlating ability of the new model is compared with existing solubility model.
Amrithaa Raghavan, Ratna Surya Alwi, Geetha Devi M, Chandrasekhar Garlapati   +3 more
doaj   +1 more source

Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement. [PDF]

ADMET DMPK, 2023
Patil L, Verma U, Rajput R, Patil P, Chaterjee A, Naik J.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

Drug Design, Development and Therapy, 2020
Fahad Mehmood Khan,1 Mahmood Ahmad,2 Hafiz Arfat Idrees1 1Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Punjab 63100, Pakistan; 2Faculty of Pharmacy, University of Central Punjab, Punjab 54000, PakistanCorrespondence:
Khan FM, Ahmad M, Idrees HA
doaj  

Modification and Solubility Enhancement of Rice Protein and Its Application in Food Processing: A Review. [PDF]

Molecules, 2023
Yang J, Meng D, Wu Z, Chen J, Xue L.
europepmc   +1 more source

Two-phase distribution in the vertical flow line of a domestic wet central heating system [PDF]

, 2013
The theoretical and experimental aspects of bubble distribution in bubbly two-phase flow are reviewed in the context of the micro bubbles present in a domestic gas fired wet central heating system.
Brunel University, Fsadni, A.M., Ge, Y.T., UCLan   +3 more
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