Results 131 to 140 of about 1,040,538 (251)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Solubility Enhancement of Cefdinir using different Pharmaceutical Approaches for Enhancement of the Drug Performance

Iraqi Journal of Pharmaceutical Sciences
              Cefdinir (CEF) is classified as a third-generation cephalosporin within class IV of the Biopharmaceutical Classification System (BCS). Consequently, it exhibits limited solubility in water, which might diminished oral bioavailability. This
Ghaidaa S. Hameed, Dalya Basil Hanna, Naamaa Naama   +2 more
doaj   +1 more source

Pharmaceutical and Pharmacological Evaluation of Amoxicillin after Solubility Enhancement Using the Spray Drying Technique. [PDF]

ACS Omega, 2022
Hassan F, Sher M, Hussain MA, Saadia M, Naeem-Ul-Hassan M, Rehman MFU, Haseeb MT, Bukhari SNA, Abbas A, Peng B, Kanwal F, Deng H.   +11 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

SOLUBILITY OF HIPPOPHAE RHAMNOIDES L. SEED OIL IN SC CO2 AND SCFE PROCESS ENHANCEMENT BY ULTRASOUND

, 2009
Dynamic method was applied to measure the solubility of oil from Hippophae rhamnoides L. seed in supercritical CO2. The experiments were carried out at pressures and temperatures ranging from 10 to 30MPa and 303 to 323K, respectively.
Jian-Zhong Yin, Bi, Ming-Shu, Zhou, Dan, Wang, Ai-Qin, Yin, Jian-Zhong, Jia, Ling-Yun   +5 more
core   +1 more source

Development of a quaternary ammonium poly (amidoamine) dendrimer-based drug carrier for the solubility enhancement and sustained release of furosemide. [PDF]

Front Chem, 2023
Murugan E, Yogaraj V.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Physicochemical characterization of veronicafolin-beta-cyclodextrin and solubility enhancement of veronicafolin-HP-beta-cyclodextrin inclusion compound

, 2005
Inclusion complexation between veronicafolin, 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone, and beta-cyclodextrin (beta-CD) was investigated by using H-1 NMR, IR, X-ray diffraction, thermo gravimetric analysis (TGA), and elemental analysis in the solid ...
Yang, YS, Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China., Yang, YS, Lu, RH, Shi, YP, Yang, AM, Zhang, YP, Shi, GF   +6 more
core  

Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug. [PDF]

Pharmaceuticals (Basel), 2023
Vij M, Dand N, Kumar L, Wadhwa P, Wani SUD, Mahdi WA, Alshehri S, Alam P, Shakeel F.   +8 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source