Results 131 to 140 of about 203,317 (299)

Novel Scintillating Materials Based on Phenyl-Polysiloxane for Neutron Detection and Monitoring

, 2013
Neutron detectors are extensively used at many nuclear research facilities across Europe. Their application range covers many topics in basic and applied nuclear research: in nuclear structure and reaction dynamics (reaction reconstruction and decay ...
Bermudez, J., Carturan, S., Cinausero, M., Collazuol, G., Degerlier, M., Gramegna, F., Maggioni, G., Marchi, T., Palma, M. Dalla, Quaranta, A.   +9 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Mevacor/Poly(vinyl acetate/2-hydroxyethyl methacrylate) as Solid Solution: Preparation, Solubility Enhancement and Drug Delivery. [PDF]

Polymers (Basel), 2023
Alassaf M, Alqahtani SM, Al Khulaifi RS, Saeed WS, Alsubaie FS, Semlali A, Aouak T.   +6 more
europepmc   +1 more source

EFFECT OF SOLUBILITY ENHANCERS ON THE SOLUBILITY OF PARACETAMOL

, 2013
Solubility plays an important role in dissolution and absorption of drug. Paracetamol has less solubility in aqueous media and belongs to class IV drug according to biopharmaceutical classification system.The aim of present study was to study the effect of different solubility enhancing agents at room temperature on the solubility of paracetamol ...
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Host-Guest Complexes of Flavanone and 4′-Chloroflavanone with Naturals and Modified Cyclodextrin: A Calorimetric and Spectroscopy Investigations

Molecules
The aim of the research was to investigate and compare the interaction between flavanones (flavanone, 4-chloro-flavanone) with potential anticancer activity and selected cyclodextrins.
Artur Stepniak, Marta Biernacka, Magdalena Malecka, Bartlomiej Palecz   +3 more
doaj   +1 more source

Correction to: Solubility enhancement of berberine-baicalin complex by the constituents of Gardenia Fruit. [PDF]

J Nat Med, 2022
Okoshi K, Uekusa Y, Narukawa Y, Kiuchi F.   +3 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Host–Guest Interaction Study of Olmesartan Medoxomil with β-Cyclodextrin Derivatives

Molecules
Olmesartan medoxomil (OLM) is a selective angiotensin II receptor antagonist used in the treatment of hypertension. Its therapeutic potential is limited by its poor water solubility, leading to poor bioavailability. Encapsulation of the drug substance by
Minodora Andor, Claudia Temereancă, Laura Sbârcea, Adriana Ledeți, Dana Emilia Man, Cristian Mornoș, Amalia Ridichie, Denisa Cîrcioban, Gabriela Vlase, Paul Barvinschi, Angela Caunii, Renata-Maria Văruţ, Cristina Maria Trandafirescu, Valentina Buda, Ionuț Ledeți, Matilda Rădulescu   +15 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source