Results 71 to 80 of about 1,040,538 (251)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

SOLUBILITY ENHANCEMENT OF NORFLOXACIN BY HYDROTROPY TECHNIQUE [PDF]

, 2014
The objective of this study is to improve the solubility of poorly water soluble anti-bacterial drug Norfloxacin by hydrotropic solubilization technique. For the present study sodium benzoate was used as hydrotropic agent. By using this hydrotropic agent
Reddy, M. Sreenivasa, Tippavajhala, Vamshi Krishna, K., Girishpai, S., Divya, Kumar, Lalit   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Hot melt extrusion aided amorphous solid dispersions of quercetin and resveratrol for solubility enhancement

Journal of Applied Pharmaceutical Research
Background: Conversion of poorly soluble drugs into amorphous solid dispersions using different carriers is a formulation approach to improve solubility.
Lakshmi Swapna Sai, Fatima S Dasankoppa, Srinivas Mutalik, Muralidhar Pisay   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Fishworks shop

, 2006
Covers OCLC #38937785, OCLC #1100114907"News from Oregon's Fish Restoration and Enhancement Program and Salmon Trout Enhancement Program."Title from captionErrors in numbering: v. 3, no. 1, spring 1998, called v. 2, no. 1; v. 3, no.

core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

IUPAC-NIST solubility data series. 81. Hydrocarbons with water and seawater - Revised and updated. Part 11. C13-C36 hydrocarbons with water [PDF]

, 2005
The mutual solubilities and related liquid-liquid equilibria of C 13-C36 hydrocarbons with water are exhaustively and critically reviewed. Reports of experimental determination of solubility in 56 chemically distinct binary systems that appeared in the ...
Owczarek, I., Zofia Maczynska, Costa Tsonopoulos, Iwona Owczarek, Huyskens, P.L., Haulait-Pirson, M-C., Kapuku, F., Marie-Claire Haulait-Pirson, Glenn T. Hefter, Colin L. Young, Barbara Wisniewska-Goclowska, David G. Shaw, Marian Goral, Maczynska, Z., Hefter, G.T., Young, C.L., Adam Skrzecz, Blazej, K., F. Kapuku, Skrzecz, A., Maczynski, A., Krystyna Blazej, Wisniewska-Goclowska, B., Tsonopoulos, C., Szafranski, A., Andrzej Szafranski, Goral, M., Shaw, D.G., Andrzej Maczynski   +28 more
core   +1 more source

Extraction of Diterpenoid Lactones of Andrographis paniculata using Liquid Solvents: Effect of Solvent’s Hildebrand Solubility Parameter on Extraction Efficiency [PDF]

, 2006
Two diterpenoid lactones responsible to the multi healing properties of Andrographis paniculata have been extracted using 16 different liquid solvents. The effect of Hildebrand solubility parameter of the solvents on solid-liquid extraction yield using ...
Kumoro, A.C., Hasan, M.
core   +1 more source

Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. Its water solubility has led to
Anthony Prandina, Lars Herfindal, Sylvie Radix, Pål Rongved, Stein O. Døskeland, Marc Le Borgne, Florent Perret   +6 more
doaj   +1 more source