Results 71 to 80 of about 203,317 (299)

Cyclodextrin-Nanosponge-Loaded Cyclo-Oxygenase-2 Inhibitor-Based Topical Gel for Treatment of Psoriatic Arthritis: Formulation Design, Development, and In vitro Evaluations

Pharmaceuticals
Background: Psoriatic arthritis (PsA), a chronic inflammatory disease, mainly affects the joints, with approximately 30% of psoriasis patients eventually developing PsA.
Umme Hani, Sharanya Paramshetti, Mohit Angolkar, Wajan Khalid Alqathanin, Reema Saeed Alghaseb, Saja Mohammed Al Asmari, Alhanouf A. Alsaab, Farhat Fatima, Riyaz Ali M. Osmani, Ravi Gundawar   +9 more
doaj   +1 more source

A solid dispersion based on milk-micelle as a drug-carrier for the enhancement of the aqueous solubility of ritonavir [PDF]

, 2015
The goal of present investigation was to evaluate the feasibility of formulating a solid-dispersion using milk-micelles as drug-carriers, to enhance the aqueous solubility of ...
Bernardez, M., Dave, Vivek S, Dhore, Pradip, Haware, Rahul V., Raut, Nishikant, Saoji, Suprit   +5 more
core   +1 more source

Selective removal of H2S from sour gases with microporous membranes. Part II. A liquid membrane of water-free tertiary amines [PDF]

, 1993
In the present study the application of a liquid membrane for selective removal of H2S from gases also containing CO2 was investigated. The liquid membrane was filled with pure methyl-di-ethanol-amine (MDEA). A theoretical model was developed to describe:
Kreulen, H., Smolders, C.A., Swaaij, W.P.M. van, Versteeg, G.F.   +3 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Application of cosolvency and cocrystallization approach to enhance acyclovir solubility

BMC Chemistry
Acyclovir (ACY) is a commonly used antiviral drug with limited aqueous solubility and poor permeability. It is administered via oral and intravenous routes.
Elham Azad Khiabani, Abolghasem Jouyban, Anahita Fathi Azarbayjani   +2 more
doaj   +1 more source

Effects of various penetration enhancers on percutaneous absorption of piroxicam from emulgels [PDF]

, 2012
A suitable emulgel formulation of piroxicam was prepared and its percutaneous permeation was investigated using Wistar rat skin and diffusion cell technique.
Azarmi, Sh, Fasihi, Z, Hallaj-Nezhadi, S, Javadzadeh, Y, Nokhodchi, A, Shokri, J   +5 more
core   +2 more sources

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi, Adebisi, Adeola O. Adebisi, Ahuja, Akiyama, Bai, Bajpai, Barbara R. Conway, Batchelor, Bazzoli, Boddupalli, Cammarota, Castro, Chun, Desai, Dunn, Dupuy, Erah, Erah, Ernst, Gal, Georgopoulos, Gåserød, Higuchi, Hixson, Iijima, Ikeda, Ishak, Kawahara, Khanvilkar, Kohri, Korsmeyer, Lee, Lehmann, Malfertheiner, Miyazaki, Moore, Murata, Murray, Najib, Nakagawa, Nayak, Norris, Park, Pasparakis, Pereira, Peter R. Laity, Peterson, Rajinikanth, Romero, Rothenbacher, Singh, Smrdel, Stops, Suerbaum, Suzuki, Umamaheshwari, Varum, Whitehead, Østberg   +59 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The development of ternary and quaternary solid dispersion based hydrotropic blends of atorvastatin calcium

Zanco Journal of Medical Sciences
Background and objective: Atorvastatin calcium (ATV) has a solubility in aqueous solutions of greater than 0.1 mg/ml to less than 1 mg/ml, which is very slightly soluble.
Suren Azad Ramadhan, Huner K. Omer
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source