Efficacy of sacubitril/valsartan sodium combined with simvastatin in treating chronic heart failure with arrhythmia and its effects on IL-6, IL-8, and TNF-α [PDF]
Journal of Medical BiochemistryBackground: To explore, in conjunction with clinical practice, the efficacy of different pharmacological treatment regimens for patients with chronic heart failure complicated by arrhythmia, and their effects on inflammatory factor levels.
Li Jingjing, Wang Zhihua
doaj +2 more sources
Simvastatin-induced neuroprotective effect after brain injury is mediated by mitochondrial protection through modulation of the 18 kDa translocator protein [PDF]
NeurotherapeuticsTraumatic brain injury (TBI) remains a leading cause of mortality and chronic disability. Among therapeutic agents investigated, simvastatin has emerged as a potential therapeutic opportunity for management of TBI although its mechanism of action has not
Reem Sakas +7 more
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Simvastatin impairs murine melanoma growth [PDF]
Lipids in Health and Disease, 2010 Background Statins induces cell cycle arrest, apoptosis, reduction of angiogenic factors, inhibition of the endothelial growth factor, impairing tissue adhesion and attenuation of the resistance mechanisms.
Barros Francisco E +8 more
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Effect of simvastatin on postoperative complications in patients undergoing one-lung ventilation during surgery: the Prevention HARP-2 randomised controlled trial. [PDF]
ThoraxGlass A +20 more
europepmc +2 more sources
Simvastatin-Loaded Nanostructured Lipid Carriers as Topical Drug Delivery System for Wound Healing Purposes: Preparation, Characterization, and In Vivo Histopathological Studies [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is a commonly used drug to reduce total cholesterol and low-density lipoprotein (LDL) levels.
Seyedeh Maryam Mousavi-Simakani +5 more
doaj +1 more source
Cardioprotective effects of simvastatin‑loaded nano‑niosomes on cardiomyocytes in cardiac ischemia [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. Cardiac ischemia is the major cause of morbidity and mortality which can be increased by Statins. This study aimed to increase the effectiveness of simvastatin in the form of niosomes. Methods. In this study, 25 male Wistar rats were divided
Nahid Aboutaleb +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2023 Hsp90 is a molecular chaperone that contributes to the activation and stabilization of client proteins. In our previous studies, we found that inhibition of Hsp90 delayed cardiac remodeling during the development of chronic heart failure in animal models.
Tetsuro Marunouchi +7 more
doaj +1 more source
Simvastatin and Muscle: Zebrafish and Chicken Show that the Benefits are not Worth the Damage
Frontiers in Cell and Developmental Biology, 2022 Simvastatin is one of the most common medicines prescribed to treat human hypercholesterolemia. Simvastatin acts through the inhibition of cholesterol synthesis.
Laise M. Campos +7 more
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Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4
Pharmaceutical Biology, 2021 Context Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear. Objective The interaction between baicalein and simvastatin was investigated to provide reference and guidance ...
Meng Meng, Xin Li, Xiuwen Zhang, Bin Sun
doaj +1 more source
Pleiotropic effects of simvastatin in physically trained ovariectomized rats
Brazilian Journal of Medical and Biological Research, 2013 This study tested the hypothesis that simvastatin treatment can improve cardiovascular and autonomic functions and membrane lipoperoxidation, with an increased effect when applied to physically trained ovariectomized rats.
N. Bernardes +6 more
doaj +3 more sources