Results 21 to 30 of about 46,710 (255)

The effect of topical administration of simvastatin on entochondrostosis and intramembranous ossification: An animal experiment

Journal of Orthopaedic Translation, 2021
Background: Simvastatin, a drug for lowering serum cholesterol, has been shown to enhance bone regeneration, but few studies have qualitatively and quantitatively tested its effect when used topically in different animal models.
Lei Dang, Jinglin Zhu, Chunli Song
doaj   +1 more source

Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. [PDF]

, 2012
Treatment of acute lung injury (ALI) remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI ...
Vijayan, Santosh, Mörgelin Matthias, Grommes Jochen, Köppel, Thomas, Grommes, Jochen, Binneboesel, Marcel, Mörgelin, Matthias, Helene Hartwig (158829), Weber, Christian, Matthias Mörgelin (109607), Rolf Dembinski, Santosh Vijayan, Jochen Grommes (158815), Söhnlein, Oliver, Dembinski, Rolf, Drechsler, Maik, Thomas Andreas Koeppel, Oliver Soehnlein, Moergelin, Matthias, Vijayan Santosh, Dembinski Rolf, Weber Christian, Santosh Vijayan (158820), Koeppel, Thomas Andreas, Binnebösel, Marcel, Christian Weber (86566), Maik Drechsler (158824), Michael Jacobs, Maik Drechsler, Lund University., Rolf Dembinski (12675), Thomas Andreas Koeppel (158847), Koeppel Thomas Andreas, Marcel Binnebösel, Matthias Mörgelin, Jacobs, Michael, Jacobs Michael, Binnebösel Marcel, Oliver Soehnlein (158864), Michael Jacobs (105163), Hartwig Helene, Jochen Grommes, Mörgelin, Matthias,, Helene Hartwig, Marcel Binnebösel (158855), Soehnlein, Oliver, Hartwig, Helene, Drechsler Maik, Soehnlein Oliver, Christian Weber   +49 more
core   +1 more source

Multicomponent crystals: Solubility enhancement of simvastatin using arginine and glycine coformers [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Simvastatin can be modified by the formation of multicomponent crystals to increase its solubility. Aims: To compare the solubility of multicomponent simvastatin crystals to pure simvastatin. Methods: The in silico study of simvastatin and
Iyan Sopyan, Karyn Elizabeth, Sandra Megantara, Silmy Kaffah   +3 more
doaj   +1 more source

Simvastatin Attenuated Tumor Growth in Different Pancreatic Tumor Animal Models

Pharmaceuticals, 2022
Newly diagnosed pancreatic cancer increases year by year, while the prognosis of pancreatic cancer has not been very good. Statin drugs were found to have protective effects against a variety of cancers, but their association with pancreatic cancer ...
Chao-Yi Chen, Yi-Feng Yang, Paul C. Wang, Liang Shan, Stephen Lin, Po-Jung Chen, Yi-Jung Chen, Han-Sun Chiang, Jaw-Town Lin, Chi-Feng Hung, Yao-Jen Liang   +10 more
doaj   +1 more source

Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects

Pharmaceuticals, 2023
Higher risk of major hemorrhage associated with concomitant use of dabigatran and simvastatin compared to other statins was previously reported with a suggestion of P-glycoprotein-mediated interaction. The aim of this study was to evaluate the effects of
Hyewon Chung, Jong-Min Kim, Jin-Woo Park, Jihyeon Noh, Kyoung-Ah Kim, Ji-Young Park   +5 more
doaj   +1 more source

Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. [PDF]

, 2011
The rate-limiting step of cholesterol biosynthetic pathway is catalyzed by 3-hydroxy-3-methylglutaryl coenzyme reductase (HGMR), whose inhibitors, the statins, widely used in clinical practice to treat hypercholesterolemia, often cause myopathy, and ...
Moreno, Sandra, Swiezewska, Ewa, Linari, Marco, Fanelli, Francesca, V. Trezza, Segatto, Marco, L. Melli, Marco Segatto, L. p. Pucillo, Patrizia Campolongo, Pallottini, Valentina, Laura Trapani, Leopoldo Paolo Pucillo, Viviana Trezza, S. Moreno, F. Fanelli, A. Jozwiak, M. Segatto, V. Pallottini, Campolongo, Patrizia, Melli, Luca, Sandra Moreno, Francesca Fanelli, Marco Linari, Trezza, Viviana, E. Swiezewska, L. Trapani, Trapani, Laura, Valentina Pallottini, Adam Jozwiak, Luca Melli, Ewa Swiezewska, Jóźwiak, Adam, M. Linari, Pucillo, Leopoldo Paolo   +34 more
core   +1 more source

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension

Clinical and Experimental Hypertension, 2018
Background: Recent research has shown that statins improve pulmonary arterial hypertension (PAH), but their mechanisms of action are not fully understood.
Wei-Hua Liu, Xiao-Hong Xu, Qin Luo, Hong-Liang Zhang, Yong Wang, Qun-Ying Xi, Zhi-Hui Zhao, Zhi-Hong Liu   +7 more
doaj   +1 more source

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

Cellular Physiology and Biochemistry, 2013
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction.
Yu-Miao Wei, Xiang Li, Ming Xu, Justine M. Abais, Yang Chen, Christopher R. Riebling, Krishna M. Boini, Pin-Lan Li, Yang Zhang   +8 more
doaj   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
O'Kane, Cecilia M., O’Kane, Cecilia M., Laffey, John G, Cross, Mark, John G Laffey, McAuley, Daniel F; id_orcid, McNally, Christine, Michael Stevenson, Perkins, Gavin D., Crealey, Grainne, Laffey, John G., Daniel F McAuley, Murphy, Lynn, HASH(0x55a67ff73468), Stevenson, Michael, Cross, L. J. Mark, Grainne Crealey, Cecilia M O’Kane, McAuley, Daniel F., Mark Cross, null null, Gavin D Perkins, Perkins, Gavin D, Christine McNally, Lynn Murphy, O'Kane, Cecilia M   +25 more
core   +1 more source

Effects of simvastatin on apolipoprotein M in vivo and in vitro

Lipids in Health and Disease, 2011
Objective To investigate effects of lipid lowering drug, simvastatin, on apolipoprotein M expression in the hyperlipidemic mice and in hepatic cell line, HepG2 cells. Methods Swiss male mice were randomly divided into the high fat group and control group,
Nilsson-Ehle Peter, Berggren-Söderlund Maria, Wei Jiang, Luo Guanghua, Mao Shubing, Zhang Xiaoying, Xu Ning   +6 more
doaj   +1 more source