Results 11 to 20 of about 93,702 (291)

The effect of topical administration of simvastatin on entochondrostosis and intramembranous ossification: An animal experiment

Journal of Orthopaedic Translation, 2021
Background: Simvastatin, a drug for lowering serum cholesterol, has been shown to enhance bone regeneration, but few studies have qualitatively and quantitatively tested its effect when used topically in different animal models.
Lei Dang, Jinglin Zhu, Chunli Song
doaj   +1 more source

Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]

, 2015
Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut, A Hilgendorff, AA Ajibade, BI Gavrila, BP Leung, C Arnaud, C Guiducci, C Guijarro, E Munro, EH Choy, FL Zhang, FM Brennan, FM Brennan, FX Zhang, G Falgarone, H Kanda, H Kanda, H Lin, H Methe, H Okamoto, H Radner, H Wesche, H Xu, I Zelvyte, J Qin, Jason Ferdjani, K Chaabo, KA Fitzgerald, KA Fitzgerald, KH Costenbader, KI Paraskevas, L Liu, LA O’Neill, Lisa Mullen, LM Mullen, M Khoury, M Ortego, M Yamamoto, M Yoshida, MA Gonzalez-Gay, QQ Huang, S Alzabin, S Doornum Van, Sandra Sacre, SL Chinault, SM Sacre, T Mosmann, TT Tang, U Schonbeck   +48 more
core   +1 more source

Multicomponent crystals: Solubility enhancement of simvastatin using arginine and glycine coformers [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Simvastatin can be modified by the formation of multicomponent crystals to increase its solubility. Aims: To compare the solubility of multicomponent simvastatin crystals to pure simvastatin. Methods: The in silico study of simvastatin and
Iyan Sopyan, Karyn Elizabeth, Sandra Megantara, Silmy Kaffah   +3 more
doaj   +1 more source

Simvastatin Attenuated Tumor Growth in Different Pancreatic Tumor Animal Models

Pharmaceuticals, 2022
Newly diagnosed pancreatic cancer increases year by year, while the prognosis of pancreatic cancer has not been very good. Statin drugs were found to have protective effects against a variety of cancers, but their association with pancreatic cancer ...
Chao-Yi Chen, Yi-Feng Yang, Paul C. Wang, Liang Shan, Stephen Lin, Po-Jung Chen, Yi-Jung Chen, Han-Sun Chiang, Jaw-Town Lin, Chi-Feng Hung, Yao-Jen Liang   +10 more
doaj   +1 more source

Effects of Simvastatin on Pharmacokinetics and Anticoagulant Effects of Dabigatran in Healthy Subjects

Pharmaceuticals, 2023
Higher risk of major hemorrhage associated with concomitant use of dabigatran and simvastatin compared to other statins was previously reported with a suggestion of P-glycoprotein-mediated interaction. The aim of this study was to evaluate the effects of
Hyewon Chung, Jong-Min Kim, Jin-Woo Park, Jihyeon Noh, Kyoung-Ah Kim, Ji-Young Park   +5 more
doaj   +1 more source

High dose atorvastatin associated with increased risk of significant hepatotoxicity in comparison to simvastatin in UK GPRD cohort [PDF]

, 2016
Background and Aims: Occasional risk of serious liver dysfunction and autoimmune hepatitis during atorvastatin therapy has been reported. We compared the risk of hepatotoxicity in atorvastatin relative to simvastatin treatment.
Clarke, Alan T., Ford, Ian, Hall, Gillian C., Johnson, Paul C.D., Mills, Peter   +4 more
core   +3 more sources

Osteogenic effects of simvastatin-loaded mesoporous titania thin films [PDF]

, 2018
The use of statins in the field of bone regeneration is under current investigation due to the existing demand for non-toxic anabolic agents capable of enhancing bone formation in cases of substantial loss. Simvastatin, a coenzyme currently prescribed in
Angelome, Paula Cecilia, Gonzalez, Pio, Liz Marzan, Luis M, Lopez Alvarez, Miriam, López Puente, Vanesa, Pastoriza Santos, Isabel, Rodriguez Valencia, Cosme, Serra, Julia   +7 more
core   +1 more source

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension

Clinical and Experimental Hypertension, 2018
Background: Recent research has shown that statins improve pulmonary arterial hypertension (PAH), but their mechanisms of action are not fully understood.
Wei-Hua Liu, Xiao-Hong Xu, Qin Luo, Hong-Liang Zhang, Yong Wang, Qun-Ying Xi, Zhi-Hui Zhao, Zhi-Hong Liu   +7 more
doaj   +1 more source

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

Cellular Physiology and Biochemistry, 2013
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction.
Yu-Miao Wei, Xiang Li, Ming Xu, Justine M. Abais, Yang Chen, Christopher R. Riebling, Krishna M. Boini, Pin-Lan Li, Yang Zhang   +8 more
doaj   +1 more source