Results 41 to 50 of about 50,616 (252)
Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus species
Brazilian Journal of Infectious Diseases, 2015 The antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested against Candida spp.
Raimunda Sâmia Nogueira Brilhante +9 more
doaj +1 more source
Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3
Advanced Science, EarlyView.This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao +6 more
wiley +1 more source
Journal of Pharmaceutical Analysis, 2014 A simple, sensitive and specific liquid chromatographyâtandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma.
Sireesha R. Karanam +4 more
doaj +1 more source
Advanced Science, EarlyView.Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han +11 more
wiley +1 more source
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
Advanced Intelligent Discovery, EarlyView.This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source
Simvastatin Induced Rhabdomyolysis of Anterior Compartment of Leg Resulting in Foot Drop [PDF]
, 2009 A 65-year-old physically active man presented with sudden onset leg pain and inability to dorsiflex his foot following a trivial fall. There was no tenseness in the anterior compartment and compartment pressure was normal.
A I R Jenkins +3 more
core
Molecular mechanisms of statin-induced myotoxicity [PDF]
, 2011 Statins are among the most prescribed drugs in Western countries. They reduce morbidity and mortality from coronary heart disease and mitigate the risk of stroke.
Mullen, Peter James
core +1 more source
, 2021 Background/Objectives: Disseminated superficial actinic porokeratosis (DSAP) is a porokeratosis variant that is cosmetically disfiguring and may be associated with squamous cell carcinoma.
Byth, Lachlan A +3 more
core +1 more source