Results 51 to 60 of about 50,616 (252)

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Cytotoxicity and induced apoptosis of a new bioceramic cement containing simvastatin on stem cells from human exfoliated deciduous teeth

Dental Research Journal, 2022
Background: This study aims to compare cytotoxicity and induced apoptosis of a new bioceramic cement containing different concentrations of simvastatin on stem cells from human exfoliated deciduous teeth (SHED).
Iman Parisay, Ali Qeidari, Ehsan Sabouri, Fatemeh Khorakian, Hosein Bagheri   +4 more
doaj   +1 more source

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind   +17 more
wiley   +1 more source

Multifunctional polycaprolactone‐based composite fibers with icariin and glutathione for effective repair of critical‐sized bone defects

BMEMat, EarlyView.
A multifunctional PCL‐based scaffold co‐delivering Icariin and Glutathione synergistically enhances osteogenesis, angiogenesis, and oxidative stress resistance, achieving near‐complete repair of critical‐sized bone defects in vivo. This cell‐free platform represents a promising strategy for accelerated bone regeneration.
Abdurohman Mengesha Yessuf, Yaqi Zhang, Bharat Prasad Sharma, Yake Wang, Tibebu Shiferaw Kassa, Abdul Qadir, Ye Jinqiu, Mohamedazeem M. Mohideen, Ahmed M. Salama, Weiguo Wang, Qidong Zhang, Yong Liu   +11 more
wiley   +1 more source

Simvastatin-loaded liposomal nanoparticles as treatment for adenomyosis in a patient-derived xenograft mouse model: a pilot study

Journal of Obstetrics and Gynaecology
Background Adenomyosis is a common gynaecological condition where ectopic endometrial glands and stroma grow within the myometrium. This condition has a high clinical burden impacting those afflicted with debilitating symptoms including heavy painful ...
Rachel Michel, Kathleen L. Vincent, Gregory W. Kirschen, Massoud Motamedi, Jamal Saada, Jinping Yang, Bulent Ozpolat, Gokhan S. Kilic, Mostafa A. Borahay   +8 more
doaj   +1 more source

The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection. [PDF]

PLoS ONE, 2014
The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human immune regulators including pro ...
Emma Hennessy, Julie O'Callaghan, Marlies J Mooij, Claire Legendre, Olga Camacho-Vanegas, Sandra C Camacho, Claire Adams, John A Martignetti, Fergal O'Gara   +8 more
doaj   +1 more source

Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial Hypertension

Pharmaceutics, 2022
It has been hypothesized that simvastatin could be used to treat pulmonary arterial hypertension (PAH). This study is intended to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation. Simvastatin nanoparticles were prepared via an
Shalaleh Zendehdel Baher, Shadi Yaqoubi, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi   +4 more
doaj   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells

Journal of Diabetes Research, 2014
The aim of this study was to investigate the effects of simvastatin on insulin secretion in mouse MIN6 cells and the possible mechanism. MIN6 cells were, respectively, treated with 0 μM, 2 μM, 5 μM, and 10 μM simvastatin for 48 h.
Jieqiong Zhou, Weihua Li, Qiang Xie, Yuxi Hou, Shaopeng Zhan, Xi Yang, Xiaofeng Xu, Jun Cai, Zhengrong Huang   +8 more
doaj   +1 more source

Efficacy of sacubitril/valsartan sodium combined with simvastatin in treating chronic heart failure with arrhythmia and its effects on IL-6, IL-8, and TNF-α [PDF]

Journal of Medical Biochemistry
Background: To explore, in conjunction with clinical practice, the efficacy of different pharmacological treatment regimens for patients with chronic heart failure complicated by arrhythmia, and their effects on inflammatory factor levels.
Li Jingjing, Wang Zhihua
doaj   +1 more source