Results 51 to 60 of about 93,702 (291)

The Study of the Influence of Formulation and Process Variables on the properties of Simvastatin-Phospholipid Complex [PDF]

, 2016
Objectives: The aim of the present study was to examine the influence of the formulation and process variables on the entrapment efficiency of simvastatin-phospholipid complex (SPC), prepared with a goal of improving the solubility and permeability of ...
Belgamwar, Veena S., Dave, Vivek S, Dharashivkar, Sanket S., Mack, Connor, Rode, Aniket A., Saoji, Suprit   +5 more
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells

Journal of Diabetes Research, 2014
The aim of this study was to investigate the effects of simvastatin on insulin secretion in mouse MIN6 cells and the possible mechanism. MIN6 cells were, respectively, treated with 0 μM, 2 μM, 5 μM, and 10 μM simvastatin for 48 h.
Jieqiong Zhou, Weihua Li, Qiang Xie, Yuxi Hou, Shaopeng Zhan, Xi Yang, Xiaofeng Xu, Jun Cai, Zhengrong Huang   +8 more
doaj   +1 more source

Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus species

Brazilian Journal of Infectious Diseases, 2015
The antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested against Candida spp.
Raimunda Sâmia Nogueira Brilhante, Erica Pacheco Caetano, Jonathas Sales de Oliveira, Débora de Souza Collares Maia Castelo-Branco, Elizabeth Ribeiro Yokobatake Souza, Lucas Pereira de Alencar, Rossana de Aguiar Cordeiro, Tereza de Jesus Pinheiro Gomes Bandeira, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha   +9 more
doaj   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Simultaneous determination of ezetimibe and simvastatin in rat plasma by stable-isotope dilution LC-ESI–MS/MS and its application to a pharmacokinetic study

Journal of Pharmaceutical Analysis, 2014
A simple, sensitive and specific liquid chromatography–tandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma.
Sireesha R. Karanam, Prakash Katakam, Babu R. Chandu, Nagiat T. Hwisa, Shanta K. Adiki   +4 more
doaj   +1 more source

Dry Powder Formulation of Simvastatin Nanoparticles for Potential Application in Pulmonary Arterial Hypertension

Pharmaceutics, 2022
It has been hypothesized that simvastatin could be used to treat pulmonary arterial hypertension (PAH). This study is intended to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation. Simvastatin nanoparticles were prepared via an
Shalaleh Zendehdel Baher, Shadi Yaqoubi, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi   +4 more
doaj   +1 more source

Blood cholesterol levels of hypercholesterolemic rat (Rattus norvegicus) after VCO treatment [PDF]

, 2009
Abstrak. Harini M, Astirin OP. 2009. Kadar kolesterol darah tikus putih (Rattus norvegicus) hiperkolesterolemik setelah perlakuan VCO. Nusantara Bioscience 1: 53-58.
ASTIRIN, OKID PARAMA, HARINI, MARTI
core   +2 more sources

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection. [PDF]

PLoS ONE, 2014
The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human immune regulators including pro ...
Emma Hennessy, Julie O'Callaghan, Marlies J Mooij, Claire Legendre, Olga Camacho-Vanegas, Sandra C Camacho, Claire Adams, John A Martignetti, Fergal O'Gara   +8 more
doaj   +1 more source