Results 31 to 40 of about 46,710 (255)
Journal of Tissue Engineering, 2013 The aim of this study was to develop a three-dimensional porous bone graft material as vehicle for simvastatin delivery and to investigate its effect on primary human osteoblasts from three donors.
Helen Pullisaar +6 more
doaj +1 more source
Simvastatin protects high glucose-induced H9c2 cells from injury by inducing autophagy
Pharmaceutical Biology, 2020 Context Simvastatin is the first line therapeutic drug for coronary heart disease and atherosclerosis. The protective effect mechanism of simvastatin on cardiomyocytes is unclear.
Lusha E, Hong Jiang
doaj +1 more source
Simvastatin profoundly impairs energy metabolism in primary human muscle cells
Endocrine Connections, 2020 Objectives: Simvastatin use is associated with muscular side effects, and i ncreased risk for type 2 diabetes (T2D). In clinical use, simvastatin is administered in inactive lipophilic lactone-form, which is then converted to active acid-form in the body.
Selina Mäkinen +5 more
doaj +1 more source
Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats [PDF]
Pharmaceutical Sciences, 2019 Background: Food-drug interaction can decrease drug effectiveness or increase risk of drug toxicity. Simvastatin is widely used for treatment of hypercholesterolemia and hypertriglyceridemia.
Kritsakorn Rayasilp +5 more
doaj +1 more source
Simvastatin-Loaded Lipid Emulsion Nanoparticles: Characterizations and Applications
, 2022 Simvastatin (SIM) is a diet drug to treat high lipid levels in the blood. It has the drawback of being metabolized in humans’ gastrointestinal tract (GIT) when taken in an oral dosage form.
Muhammad Farhan Ali Khan (12975678) +8 more
core +1 more source
Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway. [PDF]
PLoS ONE, 2013 Renal cell carcinoma (RCC) is the most lethal type of genitourinary cancer due to its occult onset and resistance to chemotherapy and radiation. Recently, accumulating evidence has suggested stains, inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A ...
Zhiqing Fang +10 more
doaj +1 more source
Possible Involvement of Akt Activity in Endothelial Dysfunction in Type 2 Diabetic Mice
Journal of Pharmacological Sciences, 2008 We investigated the effects of chronic simvastatin treatment on the impaired endothelium-dependent relaxation seen in aortas from type 2 diabetic mice. Starting at 8 weeks of diabetes, simvastatin (10 mg/kg per day) was administered to diabetic mice for ...
Yasuhiro Takenouchi +3 more
doaj +1 more source
Scientific Reports, 2023 Wound healing is one of the most challenging medical circumstances for patients. Pathogens can infect wounds, resulting in tissue damage, inflammation, and disruption of the healing process. Simvastatin was investigated recently, as a wound healing agent
Lamiaa M. Ahmed +3 more
doaj +1 more source
Simvastatin ameliorates oxidative stress levels in HepG2 cells and hyperlipidemic rats
Current Research in Pharmacology and Drug Discovery, 2022 Simvastatin is an established anti-hyperlipidemic drug and few studies have indicated its role in the mitigation of oxidative stress. However, a systematic study considering molecular binding/interaction of simvastatin with anti-oxidant enzymes followed ...
Kanika Verma +6 more
doaj +1 more source
Preparation of Simvastatin Hydrogel through Arginine Addition for Drug Delivery System
MATEC Web of Conferences, 2018 Simvastatin is a lipid lowering agent which has been used recently as drug delivery system for stimulating bone regeneration. Because of low therapeutic efficacy and bioavailability, it is necessary to deliver simvastatin by local administration e.g.
Rosyida Niswati Fathmah +3 more
doaj +1 more source