Possible Involvement of Akt Activity in Endothelial Dysfunction in Type 2 Diabetic Mice
Journal of Pharmacological Sciences, 2008 We investigated the effects of chronic simvastatin treatment on the impaired endothelium-dependent relaxation seen in aortas from type 2 diabetic mice. Starting at 8 weeks of diabetes, simvastatin (10 mg/kg per day) was administered to diabetic mice for ...
Yasuhiro Takenouchi +3 more
doaj +1 more source
Supra and subgingival application of antiseptics or antibiotics during periodontal therapy
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero +5 more
wiley +1 more source
Scientific Reports, 2023 Wound healing is one of the most challenging medical circumstances for patients. Pathogens can infect wounds, resulting in tissue damage, inflammation, and disruption of the healing process. Simvastatin was investigated recently, as a wound healing agent
Lamiaa M. Ahmed +3 more
doaj +1 more source
Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist. [PDF]
Clin Pharmacol TherOrforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Morse BL +7 more
europepmc +2 more sources
Preparation of Simvastatin Hydrogel through Arginine Addition for Drug Delivery System
MATEC Web of Conferences, 2018 Simvastatin is a lipid lowering agent which has been used recently as drug delivery system for stimulating bone regeneration. Because of low therapeutic efficacy and bioavailability, it is necessary to deliver simvastatin by local administration e.g.
Rosyida Niswati Fathmah +3 more
doaj +1 more source
The pleiotropic effects of simvastatin on retinal microvascular endothelium has important implications for ischaemic retinopathies. [PDF]
PLoS ONE, 2008 BackgroundCurrent guidelines encourage the use of statins to reduce the risk of cardiovascular disease in diabetic patients; however the impact of these drugs on diabetic retinopathy is not well defined.
Reinhold J Medina +4 more
doaj +1 more source
The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice [PDF]
International Journal of Ophthalmology, 2017 AIM: To investigate the retinal toxicity and pharmacokinetics of simvastatin intravitreally injected into mice. METHODS: Forty-eight 6-8-week-old C57BL/6J mice were used in this study.
Dennis Y. Tse +5 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu +17 more
wiley +1 more source
Alterations of iron metabolism during heart ischemia/reperrfusion injury. Cytoprotective effects of Simvastatin. [PDF]
, 2011 Ischemic heart disease, the main cause of mortality and morbidity in industrialized countries, is a metabolic phenomenon due to an inadequate oxygenation of heart tissue caused by the closing or narrowing of the coronary arteries.
Di Pascale, Antonio
core +1 more source
Simvastatin ameliorates oxidative stress levels in HepG2 cells and hyperlipidemic rats
Current Research in Pharmacology and Drug Discovery, 2022 Simvastatin is an established anti-hyperlipidemic drug and few studies have indicated its role in the mitigation of oxidative stress. However, a systematic study considering molecular binding/interaction of simvastatin with anti-oxidant enzymes followed ...
Kanika Verma +6 more
doaj +1 more source