Results 121 to 130 of about 220,549 (336)

Use of organotypic or three-dimensional systems with basic fibroblast growth factor for in vitro culture of immature collared peccary testicle

Reproduction and Fertility
The objective was to evaluate the effects of different culture systems and the addition of fibroblast growth factor (bFGF) during in vitro culture (IVC) of testicular tissue fragments from prepubertal collared peccaries. Testes from five individuals were
Ana Glória Pereira, Andréia Maria da Silva, Luana Grasiele Pereira Bezerra, Joana Letícia Cottin de Albuquerque, Gabriel Santos Costa Bezerra, Alexsandra Fernandes Pereira, Carlos Eduardo Bezerra de Moura, Pierre Comizzoli, Alexandre Rodrigues Silva   +8 more
doaj   +1 more source

E-cadherin expression is associated with somatostatin analogue response in acromegaly [PDF]

, 2018
Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs)
Cano, David A., Castaño, Justo P., Dios, Elena, Flores Martínez, Álvaro, Ibáñez Costa, Alejandro, Japón Rodríguez, Miguel Ángel, Luque, Raúl M., Madrazo Atutxa, Ainara, Soto Moreno, Alfonso Manuel, Venegas Moreno, Eva, Vázquez Borrego, Mari C.   +10 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exploring Factors Underlying Poorly-Controlled Asthma in Adults by Integrating Phenotypes and Genotypes Associated with Obesity and Asthma: A Case-Control Study

Journal of Asthma and Allergy, 2023
Hung-Ling Huang,1– 3,* Ying-Jhen Huang,4,* Yi-Chi Chu,4 Chia-Wei Chen,5 Hsin-Chou Yang,5 Jing-Shiang Hwang,5 Chun-Houh Chen,5 Ta-Chien Chan4,6 1Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; 2Division of Pulmonary and Critical Care ...
Huang HL, Huang YJ, Chu YC, Chen CW, Yang HC, Hwang JS, Chen CH, Chan TC   +7 more
doaj  

An ELISA for apolipoprotein M reveals a strong correlation to total cholesterol in human plasma

Journal of Lipid Research, 2007
Apolipoprotein M (apoM) is a 188 amino acid, 25 kDa protein belonging to the lipocalin protein superfamily. Although predominantly associated with high density lipoprotein, apoM is found in all major lipoprotein classes. To facilitate clinical studies of
Olof Axler, Josefin Ahnström, Björn Dahlbäck   +2 more
doaj   +1 more source

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. [PDF]

, 2018
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative ...
Abecasis, Goncalo, Alver, Maris, Bloom, Jonathan M, Chaffin, Mark, Correa, Adolfo, Cupples, L Adrienne, Engreitz, Jesse M, Ernst, Jason, Esko, Tonu, Ganna, Andrea, Johnson, W Craig, Kathiresan, Sekar, Kellis, Manolis, Khera, Amit V, Lander, Eric S, Manichaikul, Ani, Mitchell, Braxton, Montasser, May, Natarajan, Pradeep, Neale, Benjamin M, NHLBI TOPMed Lipids Working Group, O'Connell, Jeffrey R, Peloso, Gina M, Perry, James A, Poterba, Timothy, Rich, Stephen S, Ripatti, Samuli, Rotter, Jerome I, Ruotsalainen, Sanni E, Salomaa, Veikko, Seed, Cotton, Surakka, Ida L, Vasan, Ramachandran S, Willer, Cristen J, Wilson, James G, Zekavat, Seyedeh Maryam, Zhou, Wei   +36 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

I6 passages : sur la reproduction d’une lignée de cellules souches embryonnaires humaines entre Israël et la France

Socio-anthropologie
The first French clinical trial using human embryonic stem cells for regenerative purposes was launched in 2014, using the I6 stem cell line that was imported from Israel.
Noémie Merleau-Ponty, Sigrid Vertommen, Michel Pucéat   +2 more
doaj   +1 more source

Planning Today for Tomorrow’s Research: Analysis of Factors Influencing Participation in a Pediatric Cancer Research Biorepository

Frontiers in Oncology, 2018
BackgroundBiobanks have become a powerful tool that fosters biomedical research. The success of biobanks depends upon people’s perception and willingness to donate their samples for research.
Rania M. Labib, Omneya Hassanain, Maram Alaa, Safaa Ahmed, Sherif Abou El-Naga   +4 more
doaj   +1 more source

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Cell Reports, 2020
Summary: Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown.
Patrik Johansson, Cecilia Krona, Soumi Kundu, Milena Doroszko, Sathishkumar Baskaran, Linnéa Schmidt, Claire Vinel, Elin Almstedt, Ramy Elgendy, Ludmila Elfineh, Caroline Gallant, Sara Lundsten, Fernando J. Ferrer Gago, Aleksi Hakkarainen, Petra Sipilä, Maria Häggblad, Ulf Martens, Bo Lundgren, Melanie M. Frigault, David P. Lane, Fredrik J. Swartling, Lene Uhrbom, Marika Nestor, Silvia Marino, Sven Nelander   +24 more
doaj   +1 more source