Results 111 to 120 of about 171,678 (355)

Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: prospective cohort study and individual participant meta-analysis

British medical journal, 2020
Objective To compare established associations between risk factors and mortality in UK Biobank, a study with an exceptionally low rate of response to its baseline survey, against those from representative studies that have conventional response rates ...
G. Batty, C. Gale, M. Kivimäki, I. Deary, S. Bell   +4 more
semanticscholar   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evaluation of RNA purification methods by using different blood stabilization tubes: identification of key features for epidemiological studies

BMC Research Notes, 2020
Objective Peripheral blood is the most promising source of RNA biomarkers for diagnostic and epidemiological studies, because the presence of disease and prognostic information is reflected in the gene expression pattern.
J. A. Carrillo-Ávila, R. de la Puente, P. Catalina, J. D. Rejón, L. Espín-Vallejo, V. Valdivieso, R. Aguilar-Quesada   +6 more
doaj   +1 more source

An Approach to Evaluate the Costs and Outputs of Academic Biobanks.

Academic biobanks commonly report sustainability challenges, which may be exacerbated by a lack of information on biobank value. To better understand the costs and supported outputs that contribute to biobank value, we developed a systematic ...
Watson, PH, Catchpoole, DR, Rush, A, NSW Biobank Study Group,, Byrne, JA   +4 more
core   +1 more source

Whole-Exome Imputation Within UK Biobank Powers Rare Coding Variant Association and Fine-Mapping Analyses

, 2023
Exome association studies to date have generally been underpowered to systematically evaluate the phenotypic impact of very rare coding variants. We leveraged extensive haplotype sharing between 49,960 exome-sequenced UK Biobank participants and the ...
Loh, Po-Ru, Barton, Alison R., Sherman, Maxwell A., Mukamel, Ronen E.   +3 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Use of organotypic or three-dimensional systems with basic fibroblast growth factor for in vitro culture of immature collared peccary testicle

Reproduction and Fertility
The objective was to evaluate the effects of different culture systems and the addition of fibroblast growth factor (bFGF) during in vitro culture (IVC) of testicular tissue fragments from prepubertal collared peccaries. Testes from five individuals were
Ana Glória Pereira, Andréia Maria da Silva, Luana Grasiele Pereira Bezerra, Joana Letícia Cottin de Albuquerque, Gabriel Santos Costa Bezerra, Alexsandra Fernandes Pereira, Carlos Eduardo Bezerra de Moura, Pierre Comizzoli, Alexandre Rodrigues Silva   +8 more
doaj   +1 more source

Exploring Factors Underlying Poorly-Controlled Asthma in Adults by Integrating Phenotypes and Genotypes Associated with Obesity and Asthma: A Case-Control Study

Journal of Asthma and Allergy, 2023
Hung-Ling Huang,1– 3,* Ying-Jhen Huang,4,* Yi-Chi Chu,4 Chia-Wei Chen,5 Hsin-Chou Yang,5 Jing-Shiang Hwang,5 Chun-Houh Chen,5 Ta-Chien Chan4,6 1Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; 2Division of Pulmonary and Critical Care ...
Huang HL, Huang YJ, Chu YC, Chen CW, Yang HC, Hwang JS, Chen CH, Chan TC   +7 more
doaj  

An ELISA for apolipoprotein M reveals a strong correlation to total cholesterol in human plasma

Journal of Lipid Research, 2007
Apolipoprotein M (apoM) is a 188 amino acid, 25 kDa protein belonging to the lipocalin protein superfamily. Although predominantly associated with high density lipoprotein, apoM is found in all major lipoprotein classes. To facilitate clinical studies of
Olof Axler, Josefin Ahnström, Björn Dahlbäck   +2 more
doaj   +1 more source