Results 161 to 170 of about 220,549 (336)

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. [PDF]

, 2018
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10-7); of these, 16 map outside known risk-associated loci. We make two important
Afaq, Saima, Afzal, Shoaib, Ahlqvist, Emma, Almgren, Peter, Amin, Najaf, An, Ping, Bang, Lia B, Bertoni, Alain G, Bielak, Lawrence F, Bombieri, Cristina, Bork-Jensen, Jette, Brandslund, Ivan, Brody, Jennifer A, Burtt, Noël P, Canouil, Mickaël, Chen, Yii-Der Ida, Cho, Yoon Shin, Christensen, Cramer, Chu, Audrey Y, Cook, James P, de Haan, Hugoline G, Demirkan, Ayse, Eastwood, Sophie V, Eckardt, Kai-Uwe, ExomeBP Consortium, Fischer, Krista, Flannick, Jason, Gambaro, Giovanni, Gan, Wei, GIANT Consortium, Giedraitis, Vilmantas, Graff, Marielisa, Grarup, Niels, Grove, Megan L, Guo, Xiuqing, Gustafsson, Stefan, Hackinger, Sophie, Hai, Yang, Han, Sohee, Highland, Heather M, Hivert, Marie-France, Hu, Yao, Huo, Shaofeng, Isomaa, Bo, Jensen, Richard A, Justice, Anne E, Jäger, Susanne, Jørgensen, Marit E, Jørgensen, Torben, Kim, Bong-Jo, Kim, Sung Soo, Kim, Young Jin, Kitajima, Hidetoshi, Koistinen, Heikki A, Kovacs, Peter, Kravic, Jasmina, Kriebel, Jennifer, Kronenberg, Florian, Käräjämäki, Annemari, Lange, Leslie A, Lecoeur, Cécile, Lee, Jung-Jin, Lehne, Benjamin, Li, Huaixing, Li, Jin, Li, Man, Li-Gao, Ruifang, Ligthart, Symen, Lin, Keng-Hung, Liu, Dajiang J, Lohman, Kurt K, Lu, Yingchang, Läll, Kristi, MAGIC Consortium, Mahajan, Anubha, Malerba, Giovanni, Marouli, Eirini, Marten, Jonathan, Meidtner, Karina, Müller-Nurasyid, Martina, Peloso, Gina Marie, Preuss, Michael, Prins, Bram Peter, Rayner, N William, Robertson, Neil R, Rybin, Denis V, Smith, Albert Vernon, Steinthorsdottir, Valgerdur, Tajes, Juan Fernandez, Taliun, Daniel, Trubetskoy, Vassily Vladimirovich, Tybjærg-Hansen, Anne, Varga, Tibor V, Warren, Helen R, Wessel, Jennifer, Willems, Sara M, Wuttke, Matthias, Yaghootkar, Hanieh, Zhang, Weihua, Zhao, Wei   +99 more
core  

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Biobanking [PDF]

Pathobiology, 2014
openaire   +2 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Global Biobank Week: Toward Harmonization in Biobanking [PDF]

Biopreservation and Biobanking, 2017
Henderson, Marianne K., Matharoo-Ball, Balwir, Schacter, Brent, Kozlakidis, Zisis, Smits, Elke, Toernwall, Outi, Litton, Jan-Eric   +6 more
openaire   +2 more sources

Rapid Decentralized Prostate Cancer Risk Stratification by Portable Liquid Biopsy Analysis within a Clinical Biosensor Validation Framework

Advanced Science, EarlyView.
In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo, Grant Phillips, Sriganesh Srihari, Áine Farrell, Binny Jaradi, Kira J. Fitzpatrick, John W. Yaxley, Hemamali Samaratunga, Paul N. Mainwaring, Ke‐lin Ru, Darren J. Korbie, Scott A. Tomlins, Matthew J. Roberts, Robert A. Gardiner, Matt Trau   +14 more
wiley   +1 more source

Under-estimated burden of pertussis among middle and older-aged adults: A longitudinal seroepidemiological study in Taiwan during 2014–2020

Journal of Infection and Public Health
Background: The resurgence of pertussis has been observed in Taiwan in the last 2 decades. Most cases are infants and young children, and few were reported in adults.
Ming-Han Tsai, Chih-Jung Chen, Lan-Yan Yang, Yu-Bin Pan, Hsiang-Ju Shih, Chyi-Liang Chen, Cheng-Hsun Chiu   +6 more
doaj   +1 more source