Results 191 to 200 of about 99,905 (246)

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Intra-pancreatic fat deposition links to widespread systemic health risks: UK Biobank prospective cohort study. [PDF]

Insights Imaging
Cai Y, Zhao N, Mi J, Du H, Wan Z, Liu Z, Pan Y, Yan X, Fan Z, Li J, Li G, Akshintala VS, Bai X, Wu D.   +13 more
europepmc   +1 more source

Causal effects of reproductive traits on cognitive function: A two‐sample and multivariable mendelian randomization study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Potential associations between reproductive traits and cognitive function have been discovered; however, the results are inconsistent, and the causalities are unclear. This study utilized Mendelian randomization (MR) analysis to assess the causal impact of reproductive traits on cognitive function.
Xia Wang, Yunyun Guo
wiley   +1 more source

Investigate the Effects of Preeclampsia Severity, Race and Fetal Sex on Subsequent Maternal Complications Using EHR Data From Over 100,000 Pregnancies

iMetaMed, EarlyView.
We examined Preeclampsia‐associated comorbidities in the UM Discovery Cohort using confounder‐adjusted models, validated across UK Biobank, Cedars‐Sinai, and Vanderbilt, revealing condition‐specific risks supported by OR estimates and KM survival curves.
Xiaotong Yang, Haoming Zhu, Leyang Tao, Raelynn Chen, Jui‐Hsuan Chang, Zhiping P. Wang, Elizabeth S. Langen, Ashley M. Hesson, Cosmin A. Bejan, Ruowang Li, Lana X. Gamire   +10 more
wiley   +1 more source

Biobank participants' perspectives on receiving genetic risk information from a biobank - the case of haemochromatosis. [PDF]

BMC Med Genomics
Clancy J, Forstén J, Koskinen E, Arvas M, Åberg F, Pitkänen K, Castrén J.   +6 more
europepmc   +1 more source

Inadequate Zinc Intake in Adolescents Aggravates Inflammatory Bowel Disease by Inhibiting Antibody Class Switch Recombination in Mucosal B Cells Through Intestinal Microbial‐Derived KMV

iMetaMed, EarlyView.
The study reveals that inadequate zinc intake disrupts gut microbiota's ability to degrade isoleucine, leading to the accumulation of metabolite KMV. KMV inhibits antibody class‐switching in mucosal B cells by suppressing the p‐ATM‐CTIP‐Hmces pathway, impairing IgA/IgG production.
Wenbo Jiang, Yiding Geng, Bai Li, Conghui Qiao, Zijie Liu, Xinyu Shan, Xinyang Wang, Wei Wei, Tianshu Han   +8 more
wiley   +1 more source

Phage biobanks as enabling infrastructure for precision phage therapy in the era of antimicrobial resistance. [PDF]

Front Antibiot
Topa-Pila P, Morales KY, Palacios-Mora DP, Flores-Hernández C, Altamirano-Cisneros A, Gavilanes JM, Villacís-López K, Arancibia M, Mora-Domínguez J, Calero-Cáceres W.   +9 more
europepmc   +1 more source

Socioeconomic Status Modifies the Risk of Gastric Cancer Through Metabolomic Signature: Evidence From a Prospective Cohort Study

iNew Medicine, EarlyView.
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng, Shangxin Zhang, Jing Wang, Zhuoyi Wu, Wenjie Xuan, Jiawei Zhang, Qihong Zhao, Anla Hu, Jing Ni   +8 more
wiley   +1 more source

Development of biobanking infrastructure in Armenia: opportunities and challenges. [PDF]

Front Public Health
Mkrtchyan G, Avanesyan K, Ghazaryan H, Mazmanian M, Alyanakian MA, Mekinian A, Arakelyan A.   +6 more
europepmc   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source