Results 201 to 210 of about 99,905 (246)

Childhood adversity and multi-dimensional cognitive dysfunction in major depressive disorder: investigating heterogeneous effects across gender and educational in the UK Biobank. [PDF]

BMC Psychol
Li Y, Hao Z, Ren S, Zhang A, Sun N, Yang C.   +5 more
europepmc   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

The functional landscape of coding variation in the familial hypercholesterolemia gene <i>LDLR</i>. [PDF]

Science
Tabet DR, Coté AG, Lancaster MC, Weile J, Rayhan A, Fotiadou I, Kishore N, Li R, Kuang D, Knapp JJ, Carrero CS, Taverniti O, Axakova A, Castelli JMP, Islam MM, Sowlati-Hashjin S, Gandhi A, Maaieh R, Garton M, Matreyek K, Fowler DM, Bourbon M, Pfisterer SG, Glazer AM, Kroncke BM, Parikh VN, Ashley EA, Knowles JW, Claussnitzer M, Cirulli ET, Hegele RA, Roden DM, MacRae CA, Roth FP.   +33 more
europepmc   +1 more source

Young adult self‐harm: The role of victimisation and polygenic risk in a population‐based longitudinal study

JCPP Advances, EarlyView.
Abstract Background Victimisation has been associated with self‐harm (with or without suicidal intent), but little is known about this association during young adulthood—a distinct developmental period. Further, not all individuals who experience victimisation will later engage in self‐harm, suggesting the influence of other factors.
Filip Marzecki, Isabelle Ouellet‐Morin, Helena M. S. Zavos, Sylvana Côté, Richard E. Tremblay, Jean‐Philippe Gouin, Massimiliano Orri, Michel Boivin, Marie‐Claude Geoffroy   +8 more
wiley   +1 more source

Development and validation of a clinical risk prediction rule to identify inflammatory arthritis at the point of rheumatology triage. [PDF]

Rheumatol Adv Pract
Roberts JH, Demler O, Legge A, Barber CEH.   +3 more
europepmc   +1 more source

Contribution of rare variation to degenerative orthopedic diseases. [PDF]

Osteoarthr Cartil Open
Anker-Hansen C, Manderstedt E, Lind-Halldén C, Halldén C, Zöller B.   +4 more
europepmc   +1 more source

Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants. [PDF]

Nat Genet
Geller F, Wu X, Lammi V, Abner E, Valliere JT, Nastou K, Burns A, Rasmussen M, Andersson NW, Quinn L, DBDS Genomic Consortium, Aagaard B, Banasik K, Bliddal S, Boding L, Brunak S, Brøns N, Bybjerg-Grauholm J, Christoffersen LAN, Didriksen M, Dinh KM, Erikstrup C, Feldt-Rasmussen U, Grønbæk K, Kaspersen KA, Mikkelsen C, Nielsen CH, Nielsen HS, Nielsen SD, Nissen J, Sequeros CB, Tommerup N, Ullum H, Estonian Biobank Research Team, FinnGen, Spiliopoulos L, Bager P, Hviid A, Sørensen E, Pedersen OB, Lane JM, Lassaunière R, Ollila HM, Ostrowski SR, Feenstra B.   +44 more
europepmc   +1 more source

Current situation and future prospect of biobank. [PDF]

Cytojournal
Wang R, Han X, Jin L, Wang Z, Sun H, Zhang Y.   +5 more
europepmc   +1 more source

Metabolomic and proteomic signatures of gestational diabetes predicting long-term risk of type 2 diabetes: a prospective cohort study in the UK Biobank

Torres-Martos A, Michalopoulou M, Jurado-Fasoli L, Jebb SA, Carter J, Carvalho C, Aguilera CM, Astbury N, Piernas C.   +8 more
europepmc   +1 more source

The relationship between schizophrenia polygenic scores, blood-based proteins and psychosis diagnosis in the UK Biobank. [PDF]

Schizophrenia (Heidelb)
Kendall KM, Legge SE, Fenner E, Holmans P, Walters JT.   +4 more
europepmc   +1 more source