Results 221 to 230 of about 220,549 (336)

Depression and risk of gastro-oesophageal reflux disease (GERD): results from the UK Biobank study. [PDF]

BMC Gastroenterol
Reizner J, Freuer D, Schmitz T, Linseisen J, Meisinger C.   +4 more
europepmc   +1 more source

Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank

NeuroImage, 2017
F. Alfaro-Almagro, M. Jenkinson, N. Bangerter, J. Andersson, L. Griffanti, G. Douaud, S. Sotiropoulos, S. Jbabdi, Moisés Hernández-Fernández, Emmanuel Vallée, D. Vidaurre, Matthew A. Webster, Paul McCarthy, C. Rorden, Alessandro Daducci, D. Alexander, Hui Zhang, I. Dragonu, P. Matthews, K. Miller, Stephen M. Smith   +20 more
semanticscholar   +1 more source

Brain Health for Children

Brain Health, EarlyView.
ABSTRACT The World Health Organization (WHO) defines brain health as the maintenance of optimal brain integrity, good mental state, and cognitive function without significant neuropsychiatric disease. Early childhood is a critical period for brain development, which were influenced by early experiences, nutrition, and environmental factors. Disruptions
Yu Ma, Wenjuan Ma, Yue Jiang, Weiyi Chen, Yuanfeng Zhou, Yi Wang   +5 more
wiley   +1 more source

Correction: Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers. [PDF]

J Exp Med
Wouters M, Ehlers L, Van Eynde W, Kars ME, Delafontaine S, Kienapfel V, Dzhus M, Schrijvers R, De Haes P, Struyf S, Bucciol G, Itan Y, Bolze A, Voet A, Hombrouck A, Moens L, Ogunjimi B, Meyts I.   +17 more
europepmc   +1 more source

The Promoting Angiogenesis and Its Clinical Significance of CD33+Myeloid Derived Suppressor Cells Derived From Small Cell Lung Cancer

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Myeloid‐derived suppressor cells (MDSCs) are important tumor microenvironment components in small cell lung cancer (SCLC). We successfully identified MDSCs expressing the surface marker CD33 in SCLC; nonetheless, whether CD33+MDSCs promote SCLC angiogenesis remains unclear.
Heran Cui, Jingjing Liu, Peiyan Zhao, Yan Liu, Shaowei Lan, Xueli Jiang, Hui Li   +6 more
wiley   +1 more source

Use of medications with pharmacogenomic guidelines and adverse outcomes in hospitalised older patients: a retrospective cross-sectional study. [PDF]

Pharmacogenomics J
David V, McInerney CD, Tomlinson J, Bryant E, Sagoo GS, Cheong VL, Smith H, Fylan B, Rattray M.   +8 more
europepmc   +1 more source

Biobanking [PDF]

Biomedical Journal of Scientific & Technical Research, 2017
openaire   +1 more source

An Update to the Clinical Pharmacogenetics Implementation Consortium (CPIC) SLCO1B1 Allele Functionality Table Leveraging Evidence from Participants of Predominantly Sub‐Saharan African Ancestry

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) has formally updated the SLCO1B1 allele functionality table based on new evidence. Notably, the alleles studied (SLCO1B1 *9, *31, *41) are enriched in the genomes of patients historically excluded from pharmacogenomics research.
Akinyemi Oni‐Orisan, Sook Wah Yee, Tanushree Haldar, Michelle Whirl‐Carrillo, Kelly Caudle, Deepak Voora, Richard B. Kim   +6 more
wiley   +1 more source

Distinct genetic profiles of obesity have different effects on breast cancer risk: leveraging Mendelian randomisation to interrogate causal pathways and identify mediating proteins. [PDF]

Breast Cancer Res
Marchal MI, Mutie PM, Azimi T, Deng YA, Karlsson T, Johansson Å.   +5 more
europepmc   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source