Results 201 to 210 of about 18,277 (292)

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

The central biobank and virtual biobank of BIOMARKAPD

Biobanks are important resources for biomarker discovery and assay development. Biomarkers for Alzheimer's and Parkinson's disease (BIOMARKAPD) is a European multicenter study, funded by the EU Joint Programme-Neurodegenerative Disease Research, which aims to improve the clinical use of body fluid markers for the diagnosis and prognosis of Alzheimer's ...
Reijs, Babette L. R., Teunissen, Charlotte E.||, Goncharenko, Nikolai||, Betsou, Fay||, Blennow, Kaj||, Baldeiras, Inês||, Brosseron, Frederic, Cavedo, Enrica||, Fladby, Tormod||, Froelich, Lutz||, Gabryelewicz, Tomasz, Gurvit, Hakan||, Kapaki, Elisabeth N., Koson, Peter, Kulic, Luka, Lehmann, Sylvain||, Lewczuk, Piotr||, Lleó, Alberto||, Maetzler, Walter||, de Mendonça, Alexandre||, Miller, Anne-Marie, Molinuevo, José Luis||, Mollenhauer, Brit||, Parnetti, Lucilla||, Rot, Uroš, Schneider, Anja||, Simonsen, Anja Hviid||, Tagliavini, Fabrizio||, Tsolaki, Magda||, Verbeek, Marcel||, Verhey, Frans, Zboch, Marzena, Winblad, Bengt||, Scheltens, Philip||, Zetterberg, Henrik||, Visser, Pieter Jelle||   +35 more
openaire   +1 more source

Biobanking of vector-borne viruses in the Philippines: basic principles, best practices, and challenges. [PDF]

Sci Rep
Cabral LKD, Salmos JRR, Aman AYCL, Salvoza NC, Banson CJGC, De Leon JCM, Balaoeg LEB, Alonzo-Dimamay MT, Calpito KJAC.   +8 more
europepmc   +1 more source

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Institutional Biobanking as shared public health infrastructure: a financially sustainable service center model. [PDF]

Front Health Serv
Olson MV.
europepmc   +1 more source

Dihydropyrimidine Dehydrogenase Genotype–Phenotype Correlations in Plasma and Peripheral Blood Mononuclear Cells

Clinical Pharmacology &Therapeutics, EarlyView.
The chemotherapeutic 5‐fluorouracil (5‐FU) is commonly used to treat solid tumors, especially colorectal cancer. Deleterious variants in DPYD, which encodes dihydropyrimidine dehydrogenase (DPD), are strongly associated with severe and potentially lethal 5‐FU toxicity.
Brianna M. Bembenek, Seid Hamzic, Kelly J. Bouchonville, Carlo R. Largiadèr, Steven M. Offer   +4 more
wiley   +1 more source

Establishing a standardized biorepository across 3 clinical and translational science center-affiliated veterinary institutions is feasible and productive. [PDF]

Am J Vet Res
Crawford LK, Church ME, Boudreaux KA, Lapin JN, Hahn LA, Solis LJ, Wilson R, Zetterberg H, Catacci Guimaraes F, Shen S, Toedebusch RG, Vernau K, Dupanloup A, Panek W, Cameron S, Toedebusch CM.   +15 more
europepmc   +1 more source

Mental Health and Well‐Being Across the Eating Disorder Spectrum—From Milder Symptoms of Disordered Eating Behaviors to Diagnosed Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examined differences in mental health and well‐being, risk behaviors, suicidality, and social functioning across a proposed eating disorder (ED) spectrum, ranging from no ED symptoms to clinically diagnosed EDs. Methods We examined 44,303 participants in the 18‐year follow‐up in the Danish National Birth Cohort (DNBC‐18 ...
Anne V. Aurup, Andrea Joensen, Else Marie Olsen, Nadia M. Mikkelsen, Stine Danielsen, Pernille Stemann Larsen, Katrine Strandberg‐Larsen   +6 more
wiley   +1 more source

The Role that Biobanks Can Play in Driving Animal-Free Biomedical Research. [PDF]

Expert Rev Mol Med
Speirs V, Walker A.
europepmc   +1 more source