Results 221 to 230 of about 18,277 (292)

Therapeutic Target Mapping to Advance Drug Repurposing for Cardiovascular Disease: A Perspective from an Explanted Heart Biobank. [PDF]

J Pers Med
Ng C, Singhera GK, Chang EC, Samra A, Adolphs KA, Phillips EH, Bashir J, Laksman Z, Luo H, Francis GA, Lai C, Wang Y.   +11 more
europepmc   +1 more source

Rare genetic variation in adults with surgically treated temporal lobe epilepsy: An exome sequencing study

Epilepsia Open, EarlyView.
Abstract Objective To determine the frequency of monogenic variants and pathogenic copy number variants (CNVs) in adults with surgically treated temporal lobe epilepsy (TLE). Methods We performed exome sequencing (ES), including CNV analysis, in 45 adults with TLE who had previously undergone epilepsy surgery.
Antonia P. Pirker, Margot Ernst, Matias Wagner, Silvia B. Bonelli, Karin Trimmel, Judith Jud, Elisabeth Graf, Christian Dorfer, Karl Rössler, Susanne Aull‐Watschinger, Ekaterina Pataraia, Fritz Zimprich, Martin Krenn   +12 more
wiley   +1 more source

Tracheal wash culture is not associated with bronchial infection, remodelling or inflammation in horses with asthma

Equine Veterinary Journal, EarlyView.
Abstract Background Antimicrobials are commonly prescribed for the treatment of equine asthma, despite limited evidence supporting their use. Tracheal wash (TW) bacterial culture results are known to influence antimicrobial prescription decisions. Objectives To determine whether a positive TW bacterial culture in horses with asthma is associated with ...
Laurence Leduc, Guillaume St‐Jean, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

Vietnam biobanking feasibility study: An overview of biobanking landscape, infrastructure, and capacity. [PDF]

AIMS Public Health
Vu H, Cheong IH, Luong JHC, Simeon-Dubach D, Le D, Pham THX, Thanh NT, Dat NQ.   +7 more
europepmc   +1 more source

Altered gene expression in the liver and small intestine of horses with equine neuroaxonal dystrophy

Equine Veterinary Journal, EarlyView.
Abstract Background Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is the second most common diagnosis of spinal ataxia in horses in the United States. The disease develops due to a combination of vitamin E deficiency and an unknown genetic risk factor(s), and there currently is no effective treatment.
Stephanie Ryan, Blythe Durbin‐Johnson, Kevin Woolard, Andrew D. Miller, Carrie J. Finno   +4 more
wiley   +1 more source

Integrative AI-based multiomic and neurophysiological profiling of chronic pain in rheumatoid arthritis: study protocol for the prospective, observational, case-control RA-PAIN-AI study. [PDF]

BMJ Open
Skotny A, Ptaszkowski K, Kościelska-Kasprzak K, Bugaj B, Oleksy M, Stanaszek W, Tomasiewicz B, Gwozdziewicz K, Kiszka M, Tanski W.   +9 more
europepmc   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Beyond Conventional PDOs: Organoids for Tumorigenesis for Gut Cancer Modeling and Fast Clinical Decision

Gut Medicine, EarlyView.
ABSTRACT Reproducing tumor biology in vivo using three‐dimensional organoids remains a debated topic in the cancer organoid field, despite the new FDA framework for evaluating cancer drugs with organoid models. Compared with patient‐derived organoids (PDOs), which offer a humanized model for testing cancer therapies, organoids derived from normal stem ...
Chong Gao
wiley   +1 more source

SCANDARE: an institutional dynamic prospective interventional biobanking study. [PDF]

BMC Cancer
Lamy C, Laurent L, Choussy O, Pouget N, Lecuru F, Reyal F, Plissonnier AS, Kadi A, Berger F, Martin J, Dubray-Vautrin A, Marret G, Borcoman E, Romano E, Sablin MP, Cabel L, Pasquesoone C, Lantz O, Louis D, Gorret D, Da Silva ID, Mariani O, Delattre O, Bièche I, Servant N, Rodrigues M, Pierga JY, Seban RD, Marangoni E, Morillon A, Théry C, Proudhon C, Piaggio E, Vallot C, Mechta-Grigoriou F, Flavius J, Dupain C, Gentric G, Vincent-Salomon A, Kamal M, Le Tourneau C.   +40 more
europepmc   +1 more source

Development of a patient advocate committee for a pediatric biobank. [PDF]

Res Involv Engagem
Argento F, Devlin M, Dorna S, Flegg K, Prunier M, Regan T, Ristevski I, Tarabey L, Dimaras H.   +8 more
europepmc   +1 more source