Results 211 to 220 of about 61,606 (334)

The Promoting Angiogenesis and Its Clinical Significance of CD33+Myeloid Derived Suppressor Cells Derived From Small Cell Lung Cancer

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Myeloid‐derived suppressor cells (MDSCs) are important tumor microenvironment components in small cell lung cancer (SCLC). We successfully identified MDSCs expressing the surface marker CD33 in SCLC; nonetheless, whether CD33+MDSCs promote SCLC angiogenesis remains unclear.
Heran Cui, Jingjing Liu, Peiyan Zhao, Yan Liu, Shaowei Lan, Xueli Jiang, Hui Li   +6 more
wiley   +1 more source

Intergenerational justice, the impending sixth mass extinction, reproduction and advanced biotechnologies, and humanity's future. [PDF]

Camb Prism Extinct
Browne RK.
europepmc   +1 more source

Biobanking [PDF]

Biomedical Journal of Scientific & Technical Research, 2017
openaire   +1 more source

An Update to the Clinical Pharmacogenetics Implementation Consortium (CPIC) SLCO1B1 Allele Functionality Table Leveraging Evidence from Participants of Predominantly Sub‐Saharan African Ancestry

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) has formally updated the SLCO1B1 allele functionality table based on new evidence. Notably, the alleles studied (SLCO1B1 *9, *31, *41) are enriched in the genomes of patients historically excluded from pharmacogenomics research.
Akinyemi Oni‐Orisan, Sook Wah Yee, Tanushree Haldar, Michelle Whirl‐Carrillo, Kelly Caudle, Deepak Voora, Richard B. Kim   +6 more
wiley   +1 more source

Perspectives from the 2025 ISCBI/ISCI joint workshop on genetic stability, clonal monitoring, ethical data governance, and global inclusion in stem cell banking. [PDF]

Stem Cell Res Ther
Kim JH, Kurtz A, Barbaric I, Inamdar MS, Pera MF, Benvenisty N, Shakiba N, Isasi R, Hanatani T, Stacey G.   +9 more
europepmc   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Incorporating biobanking into the future of healthcare: exploring patient and healthcare worker perspectives at a Canadian tertiary academic hospital. [PDF]

Eur J Hum Genet
Usta S, Kundu N, Gowlett-Park D, Lin A, Misura A, Czibere K, Zhang L, Bigun O, Sasso R, Gunalingam T, Ukpong W, Khazaee T, Wong B, Matsumura S, Tsui H, Chow S.   +15 more
europepmc   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Design and validation of an automated healthcare-integrated biobanking algorithm for identification of advanced chronic kidney disease. [PDF]

Comput Struct Biotechnol J
Fischer C, Betz B, Stolp J, Ammon D, Scherag A, Kiehntopf M.   +5 more
europepmc   +1 more source

Before Symptoms Begin: Immune Activation in Preclinical ALS

Annals of Neurology, EarlyView.
Adriano Chiò, Andrea Calvo
wiley   +1 more source