Results 51 to 60 of about 18,277 (292)

Human iPSC Reprogramming Success: The Impact of Approaches and Source Materials

Stem Cells International
Since their discovery, human induced pluripotent stem cells (hiPSCs) have been instrumental in biomedical research, particularly in the fields of disease modelling, drug screening and regenerative therapies.
Tatyana Pozner, Christine Grandizio, Matthew W. Mitchell, Nahid Turan, Laura Scheinfeldt   +4 more
doaj   +1 more source

Determinants of the willingness to participate in biobanking among Malaysian stakeholders in the Klang Valley

BMC Medical Research Methodology, 2018
Background The demand in biobanking for the collection and maintenance of biological specimens and personal data from civilians to improve the prevention, diagnosis and treatment of diseases has increased notably. Despite the advancement, certain issues,
Latifah Amin, Hasrizul Hashim, Zurina Mahadi, Khaidzir Ismail   +3 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Biobanks—A Platform for Scientific and Biomedical Research

Diagnostics, 2020
The development of biomedical science requires the creation of biological material collections that allow for the search and discovery of biomarkers for pathological conditions, the identification of new therapeutic targets, and the validation of these ...
Kristina Malsagova, Artur Kopylov, Alexander Stepanov, Tatyana Butkova, Alexandra Sinitsyna, Alexander Izotov, Anna Kaysheva   +6 more
doaj   +1 more source

Understanding the impact of spinal cord injury on the microbiota of healthy skin and pressure injuries

Scientific Reports, 2023
Pressure injuries (PI) are a common issue among individuals with spinal cord injury (SCI), especially in the sitting areas of the body. Considering the risk of infections occurring to PI during the wound healing process, the skin microbiome is likely to ...
Reto Wettstein, Ezra Valido, Joel Buergin, Alexander Haumer, Nicole Speck, Simona Capossela, Jivko Stoyanov, Alessandro Bertolo   +7 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

He Tangata Kei Tua: Guidelines for Biobanking with Māori [PDF]

, 2016
Māori ethical frameworks recognise that all research in New Zealand is of interest to Māori and outline community expectations of appropriate behavior in research to deliver the best outcomes for Māori.
Hudson, Maui, Milne, Moe, Smith, Barry, Toki, Valmaine, Wilcox, Phillip, Russell, Khyla, Port, Waiora, Uerata, Lynley, Uerata, Lynley Moana, Wilcox, Phillip L., Beaton, Angela   +10 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ethics and biobanks [PDF]

British Journal of Cancer, 2008
Biobank research has been the focus of great interest of scholars and regulatory bodies who have addressed different ethical issues. On the basis of a review of the literature it may be concluded that, regarding some major themes in this discussion, a consensus seems to emerge on the international scene after the regular exchange of arguments in ...
openaire   +2 more sources