Results 51 to 60 of about 27,233 (308)

Precision medicine in cancer: Challenges and recommendations from an EU-funded cervical cancer biobanking study [PDF]

, 2016
Background:Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and ...
Bagrintseva, K. (Ksenia), Balint, B. (Balazs), Berns, P.M.J.J. (Els), De Koning, L. (Léanne), Hupé, P. (Philippe), Jordanova, E.S. (Ekaterina S.), Kamal, M. (Maud), Kamoun, C. (Choumouss), Kenter, G.G. (Gemma ), Kereszt, A. (Attila), Luscap-Rondof, W. (Windy), Popovic, M. (Marina), Samuels, S. (Sanne), Scholl, S.M. (Susy M.), Von Der Leyen, H. (Heiko), Wittkop, U. (Ulrike)   +15 more
core   +7 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A scoping review of considerations and practices for benefit sharing in biobanking

BMC Medical Ethics, 2021
Background Despite the rapid global growth of biobanking over the last few decades, and their potential for the advancement of health research, considerations specific to the sharing of benefits that accrue from biobanks have received little attention ...
Allan Sudoi, Jantina De Vries, Dorcas Kamuya   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Qualitative study of knowledge and attitudes to biobanking among lay persons in Nigeria

BMC Medical Ethics, 2012
Background Interest in biobanking for collection of specimens for non-communicable diseases research has grown in recent times. This paper explores the perspectives of Nigerians on donation of specimen for the biobanking research. Methods We conducted 16
Igbe Michael A, Adebamowo Clement A
doaj   +1 more source

Enhancing reuse of data and biological material in medical research : from FAIR to FAIR-Health [PDF]

, 2018
The known challenge of underutilization of data and biological material from biorepositories as potential resources formedical research has been the focus of discussion for over a decade. Recently developed guidelines for improved data availability and
Casati, Sara, Dagher, Georges, Gabriele, Anton, Holub, Petr, Kohlmayer, Florian, Koumakis, Lefteris, Kozera, Łukasz, Lavitrano, Marialuisa, Litton, Jan-Eric, Martin, Gillian M., Mendy, Maimuna, Ommen, GertJan B. van, Prasser, Fabian, Schlunder, Irene, Sezerman, Osman Ugur, Strapagiel, Dominik, Th. Mayrhofer, Michaela, Valik, Dalibor, Wutte, Andrea, Zanetti, Gianluigi, Zatloukal, Kurt   +20 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies

Translational Neurodegeneration, 2022
Background Axons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).
Yasmine Y. Fathy, Laura E. Jonkman, John J. Bol, Evelien Timmermans, Allert J. Jonker, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg   +6 more
doaj   +1 more source

Proceedings of the 3rd Indian Cancer Genome Atlas Conference 2022: Biobanking to Omics: Collecting the Global Experience

JCO Global Oncology, 2023
On January 13th and 14th 2022, the Center for Translational Cancer Research organized the virtual third Indian Cancer Genome Atlas (ICGA) Conference 2022 “Biobanking to Omics – Collecting the Global Experience.” This conference was planned as the ...
Sneha Joshi, Rupa Mishra, Madhura Kulkarni, Devaki A. Kelkar, Keerthi Harikrishnan, Pooja Vaid, Gomathi V, Jisha John, Siddhi Tamhane, Anand Deshpande, Sunil Badve, Chintamani, Ravi Mehrotra, L.S. Shashidhara, Ashutosh Kothari, Chaitanyanand Koppiker   +15 more
doaj   +1 more source

Biobanks in Europe: Prospects for Harmonisation and Networking [PDF]

, 2010
Biobanks (i.e. the organised collections consisting of biological samples and associated data, have gained great significance for research and personalised medicine) are increasingly recognised as a crucial infrastructure for research.
A. SCERRI Christian, BRAUN Anette, DESCHÊNES Mylène, FORTIER Isabel, IBARRETA RUIZ Dolores, LAAGE-HELLMAN Jens, PACI Daniele, RIJKERS-DEFRASNE Sylvie, SCHULTE IN DEN BÄUMEN Tobias, ZIKA Eleni   +9 more
core   +1 more source