Results 61 to 70 of about 26,930 (292)

Population's perspectives toward biobanks in scientific research: a study from Jordan. [PDF]

, 2019
BackgroundBiobanks (biorepositories) were established to compile collected bio-specimens for future research and usage. The collection/storage of bio-specimens triggers several social, legal, and ethical implications where public attitudes can represent ...
Al-Delaimy, Wael, Alrabadi, Nasr, Alzoubi, Karem H, Khabour, Omar F, Makhlouf, Hanin   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies

Translational Neurodegeneration, 2022
Background Axons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).
Yasmine Y. Fathy, Laura E. Jonkman, John J. Bol, Evelien Timmermans, Allert J. Jonker, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg   +6 more
doaj   +1 more source

Knowledge, perceptions and attitude of Egyptian physicians towards biobanking issues.

PLoS ONE, 2021
ObjectivesCollection and storage of biospecimens and data for biobanking raise many ethical concerns. Stakeholders' opinions about these ethical issues are important since they can help in the development of ethical guidelines to govern biobanking ...
Ahmed Samir Abdelhafiz, Eman A Sultan, Hany H Ziady, Douaa M Sayed, Walaa A Khairy   +4 more
doaj   +1 more source

Managing Access to Biobanks:How Can We Reconcile Privacy and Public Interests in Genetic Research? [PDF]

, 2010
This article is concerned with the ultimate objectives of genetic biobanks set up to promote the public interest—being the sharing of samples and data for medical research—and the consequences for personal privacy of realising them.
Frenkel, D. A., Krajewska, Atina, Laurie, G., Mallia, P., Moniz, H., Nordal, S., Pitz, C., Sandor, J.   +7 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Optimized bacterial community characterization through full-length 16S rRNA gene sequencing utilizing MinION nanopore technology

BMC Microbiology
Background Accurate identification of bacterial communities is crucial for research applications, diagnostics, and clinical interventions. Although 16S ribosomal RNA (rRNA) gene sequencing is a widely employed technique for bacterial taxonomic ...
Alessandro Bertolo, Ezra Valido, Jivko Stoyanov   +2 more
doaj   +1 more source

Benefit sharing in genomic and biobanking research in Uganda: Perceptions of researchers and research ethics committee members

Frontiers in Genetics, 2022
Background: Genomic and biobanking research has increased in Africa over the past few years. This has raised pertinent ethical, legal, and societal concerns for stakeholders such as sample or data ownership, commercialization, and benefit sharing.
Erisa Sabakaki Mwaka, Godfrey Bagenda, Deborah Ekusai Sebatta, Sylvia Nabukenya, Ian Munabi   +4 more
doaj   +1 more source

Interview with the Coordinator Prof. Giuseppe Di Giovanni, University of Malta, Department of Physiology and Biochemistry [PDF]

, 2015
Interview with the Coordinator of the Malta Neuroscience Network Programme, Prof. Giuseppe Di Giovanni regarding the Malta Neuroscience Net- work. "With the creation of the Malta Neuroscience Network, we will be keeping up with the most important ...
Di Giovanni, Giuseppe
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source