Results 81 to 90 of about 27,233 (308)
NEAT1 and Paraspeckles in Cancer Development and Chemoresistance
Non-Coding RNA, 2020 Non-coding RNA were previously thought to be biologically useless molecules arising from simple transcriptional noise. These are now known to be an integral part of cellular biology and pathology.
Gabriel Pisani, Byron Baron
doaj +1 more source
Assessing the risk of an emerging zoonosis of worldwide concern : anisakiasis [PDF]
, 2017 The authors sincerely thank the Biobanking platform at the PARASITE project (EU FP7 PARASITE project (GA no. 312068)) for providing host-parasite data.
Bao Dominguez, Miguel +8 more
core +2 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Alzheimer’s Research & TherapyBackground The hippocampus is highly affected in neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). The relationship between neuropathology and atrophy in hippocampal subfields is complex due to differences in ...
Maud M. A. Bouwman +5 more
doaj +1 more source
Blockchain in Healthcare TodayIntroduction: Scientists use donated biospecimens to create organoids, miniature copies of patient tumors1 that are revolutionizing precision medicine2 and drug discovery.
William Sanchez +4 more
doaj +1 more source
The Socio-genetic marginalization in Asia programme (SMAP) [PDF]
, 2005 SMAP, the Socio-genetic Marginalization in Asia Programme, which started off in August 2004, is a research programme set up with the support of the Netherlands Science Organisation (NWO), IIAS, and the Amsterdam School for Social Science Research (ASSR).
Sleeboom-Faulkner, Margaret
core
Closure of a human tissue biobank: Individual, institutional, and field expectations during cycles of promise and disappointment [PDF]
, 2015 Biobanks are increasingly being established to act as mediators between patient-donors and researchers. In practice, some of these will close. This paper details the experiences of one such bank.
Brown N., Seiffert D., Van Lente H.
core +2 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Governing the post mortem procurement of human body material for research [PDF]
, 2015 Human body material removed post mortem is a particularly valuable resource for research. Considering the efforts that are currently being made to study the biochemical processes and possible genetic causes that underlie cancer and cardiovascular and ...
Capitaine, Laura +3 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source