Results 101 to 110 of about 19,244 (227)

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

3D-Printed Platforms for Enzyme Immobilisation Screening and Direct Translation into Continuous-Flow Biocatalysis. [PDF]

ChemSusChem
Marchetti S, Palmara G, Tinajero C, Lisintuña LD, de Oliveira PR, Zanatta M, Sans V.   +6 more
europepmc   +1 more source

A Plasmonic Biohybrid With an Intracellular Biogenic S‐Scheme Nano‐Heterojunction Toward Wide‐Spectrum Solar‐To‐Chemical Conversion Beyond Nature

Aggregate, Volume 7, Issue 8, August 2026.
Bioinorganic hybrids show promise for solar‐to‐chemical conversion, yet are limited by poor light absorption and charge separation. A plasmonic biohybrid (CuS/CdS@yeast), featuring an intracellular S‐scheme heterojunction to achieve efficient electron‐hole separation, is fabricated via in‐situ mineralization for wide‐spectrum solar‐to‐chemical ...
Heng Yu, Tingting Guo, Guanglei Ma, Xueqing Ren, Yue Zhang, Ruijuan Qi, Nana Ma, Meilin Wei, Yi Chang, Xiaoming Ma   +9 more
wiley   +1 more source

High-titer 2-phenylethanol production in Escherichia coli via decarboxylation-step optimization and a vegetable-oil overlay for biocompatible in situ recovery. [PDF]

J Biol Eng
Liu C, Zhang H, Xing W, Na R, Meng X, Huang S, Wang L, Cao G, Wang P.   +8 more
europepmc   +1 more source

Structure‐Guided Engineering of a Ser192Ala Variant Enhances Bidirectional Catalysis in Amycolatopsis sulphurea L‐Alanine Dehydrogenase

ChemCatChem, Volume 18, Issue 15, 14 August 2026.
A rationally engineered Ser192Ala variant of Amycolatopsis sulphurea L‐alanine dehydrogenase (L‐AlaDH) exhibits ∼2‐fold higher catalytic efficiency in both reductive amination and oxidative deamination. Experimental characterization confirms maintained stability under tested conditions, highlighting its potential as an improved biocatalyst for ...
Tuba Okur Aksu, Fatih Aktaş, Onur Serçinoğlu, Barış Binay   +3 more
wiley   +1 more source

Correction: The PurR family transcriptional regulator promotes butenyl-spinosyn production in Saccharopolyspora pogona. [PDF]

Appl Microbiol Biotechnol
Li X, Wang J, Su C, Guo C, Xu Z, Wang K, Pang J, Lv B, Wang C, Li C.   +9 more
europepmc   +1 more source

Valorization of Yacon (Smallanthus sonchifolius) peel for peroxidase production and its immobilization on alginate beads for 2,4‐dichlorophenol bioconversion

The Canadian Journal of Chemical Engineering, Volume 104, Issue 8, Page 3984-3995, August 2026.
Sodium alginate was modified with EDC/NHS for the immobilization of Yacon peel peroxidase, resulting in a novel biocatalyst for the oxidation of 2,4‐dichlorophenol. Abstract Yacon (Smallanthus sonchifolius) roots are emerging as an alternative source of peroxidase. This study aimed to extract, immobilize, and characterize the peroxidase from Yacon peel,
Mariana Gomes Oliveira, Marcela Pires Spaolonzi, Carla Ivane Ganz Vogel, Aniela Pinto Kempka, Everton Skoronski   +4 more
wiley   +1 more source

Synergistic Anti‐Obesity Effect of Akkermansia muciniphila AKM Lab‐01 and Garcinia cambogia Extract via Gut Microbiota Remodeling in Diet‐Induced Obese Mice

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Combined administration of pasteurized Akkermansia muciniphila (AKM Lab‐01) and Garcinia cambogia extract (GCE) alleviates high‐fat‐diet‐induced obesity in mice by reducing adiposity, metabolic disturbances, and adipose inflammation, while remodeling gut microbiota and adipose transcriptome, revealing a gut‐host metabolic axis that underpins the ...
Baojia Huang, Zhipeng Chen, Wenbin Xue, Zilun Pu, Yalin Zhou, Sherlyn Sze Ning Koay, Ping Kong, Yingying Zhao, Lihong Tai, Zhou Lan, Yibo Xian, Amanda Juan Chen   +11 more
wiley   +1 more source

Correction: Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels. [PDF]

J Nanobiotechnology
Li M, Zhou S, Zhang S, Xie X, Nie J, Wang Q, Ma L, Cheng Y, Luo J.   +8 more
europepmc   +1 more source

Engineering the substrate scope of the thermostable phenolic acid decarboxylase N31 towards sterically hindered phenolic acids

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Phenolic acid decarboxylases (PADs) convert bio‐based hydroxycinnamic acids into valuable hydroxystyrene monomers under mild reaction conditions. These compounds are in high demand in polymer production, cosmetics, and flavoring. Especially 4‐vinyl syringol, the decarboxylation product from sinapic acid, generates polymers with similar thermal
Kristin K. F. Bauer, Sonja Vaupel, Jacques Gay, Eva Vos, Aron Wanz, Daniel Kracher, Tobias Schöngassner, Lars‐Erik Meyer, Shina C. L. Kamerlin, Selin Kara, Robert Kourist   +10 more
wiley   +1 more source