Results 151 to 160 of about 47,665 (229)

SegDesign: A modular framework for controllable protein segment engineering

open access: yesProtein Science, Volume 35, Issue 4, April 2026.
Abstract Local protein structure engineering, such as targeted remodeling of loops or flexible regions, is critical for mechanistic studies and protein optimization but remains challenging to perform in a controllable and reproducible manner. Despite advances in protein foundation models and generative structure design, most existing methods emphasize ...
Chenjie Feng   +6 more
wiley   +1 more source

ProteinMCP: An agentic AI framework for autonomous protein engineering

open access: yesProtein Science, Volume 35, Issue 4, April 2026.
Abstract Computational protein design is often constrained by slow, complex, inaccessible, and highly sophisticated and expert‐dependent workflows that hinder its transferrability and generalization power for broader applications. We present ProteinMCP, an agentic AI framework designed to accelerate and democratize protein engineering.
Xiaopeng Xu   +6 more
wiley   +1 more source

Promotor screening with reporter proteins for the yeast Starmerella bombicola [PDF]

open access: yes, 2014
De Maeseneire, Sofie   +3 more
core  

Stereoselective Bio‐Organocatalytic Cascade to Chiral Amides as Active Pharmaceutical Ingredient Intermediates Using ω‐Transaminase and Choline Chloride Under Microwave Irradiation

open access: yesChemSusChem, Volume 19, Issue 6, 27 March 2026.
Amide bond formation is central to active pharmaceutical ingredient (API) synthesis. A bio‐organocatalytic cascade is reported, merging stereoselective ω‐transaminase (ω‐TA) transamination in neat organic solvent with choline chloride‐mediated amidation under solvent‐free microwave conditions.
Salvatore Romano   +7 more
wiley   +1 more source

Structured Electrodes Enable High‐Rate and Selective Electrochemical Nicotinamide Adenine Dinucleotide Regeneration for Biocatalysis

open access: yesChemSusChem, Volume 19, Issue 6, 27 March 2026.
Direct electrochemical regeneration of the key enzymatic cofactor NADH is demonstrated in a scalable zero‐gap electrolyzer. Systematic screening of copper, silver, and titanium catalysts reveals that titanium felt achieves 100% selectivity for active 1,4‐NADH, while optimized copper mesh delivers record reaction rates. Electrode structuring and current
Jonas Wolf   +7 more
wiley   +1 more source

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