Results 51 to 60 of about 32,636 (240)

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

Biocatalysis for Biobased Chemicals

Biomolecules, 2013
The design and development of greener processes that are safe and friendly is an irreversible trend that is driven by sustainable and economic issues.
Rubén de Regil, Georgina Sandoval
doaj   +1 more source

IRES-mediated Pichia pastoris cell-free protein synthesis

Bioresources and Bioprocessing, 2023
Cell-free protein synthesis (CFPS) system is an ideal platform for fast and convenient protein research and has been used for macromolecular assembly, unnatural amino acid embedding, glycoprotein production, and more.
Yanan Wang, Ting Wang, Xinjie Chen, Yuan Lu   +3 more
doaj   +1 more source

Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles

Advanced Science, EarlyView.
We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu, Youzhi Xu, Weitao Zhang, Yongyue Ning, Yaojia Jiang, Yongquan Ning, Genping Huang, Jiawei Cheng, Paramasivam Sivaguru, Xihe Bi   +9 more
wiley   +1 more source

Hydride Transfer for NADH Regeneration: From Nature, Beyond Nature

Advanced Energy & Sustainability Research, 2023
The transfer of energy through hydrides is of particular significance in the biocatalysis field. In nature, some enzymes proceed the cascaded hydride transfers via nicotinamide adenine dinucleotide (NADH) with high selectivity in mild conditions ...
Wenshuo Wang, Jian Liu
doaj   +1 more source

Cofactor F420-Dependent Enzymes: An Under-Explored Resource for Asymmetric Redox Biocatalysis

, 2019
The asymmetric reduction of enoates, imines and ketones are among the most important reactions in biocatalysis. These reactions are routinely conducted using enzymes that use nicotinamide cofactors as reductants.
Colin Scott, James Antoney, Carol J. Hartley, Mihir V. Shah, Suk Woo Kang, Hadi Nazem-Bokaee, Colin J. Jackson, Andrew C. Warden   +7 more
core   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

Advanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko, Eric S. Larsen, Govind Paneru, Kisung Lee, Diana V. Kolygina, Yankai Jia, Elizabeth Maria Clarissa, Wai‐Shing Wong, Bartosz A. Grzybowski   +8 more
wiley   +1 more source

Integrating biocatalysis with continuous flow: current status, challenges, and future perspectives

Journal of Advanced Research
Background: Continuous-flow biocatalysis is gaining attention for the synthesis of highly valuable pharmaceuticals and fine chemicals. The integrated approach combines the high activity and selectivity of biocatalysts with the superior efficiency in mass
Jing Bai, Chen Huang, Yunting Liu, Xiaobing Zheng, Jianqiao Liu, Liya Zhou, Jinlong Liu, Yanjun Jiang   +7 more
doaj   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Marine Biocatalysts: Enzymatic Features and Applications

Marine Drugs, 2011
In several recent reports related to biocatalysis the enormous pool of biodiversity found in marine ecosystems is considered a profitable natural reservoir for acquiring an inventory of useful biocatalysts.
Antonio Trincone
doaj   +1 more source