Results 71 to 80 of about 31,860 (265)
Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles
Advanced Science, EarlyView.We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu +9 more
wiley +1 more source
Protein immobilization technology for flow biocatalysis [PDF]
, 2020 Enzymatic immobilization has been at the forefront of applied biocatalysis as it enables convenient isolation and reuse of the catalyst if the target reaction is conducted in batch, and it has opened up significant opportunities to conduct biocatalysis ...
Romero-Fernández, María +1 more
core +3 more sources
Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis
Advanced Science, EarlyView.Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko +8 more
wiley +1 more source
Diversifying Arena of Drug Synthesis: In the Realm of Lipase Mediated Waves of Biocatalysis
, 2021 Hydrolases, being most prominent enzymes used in industrial processes have left no stone unturned in fascinating the pharmaceutical industry. Lipases, being a part of acyl hydrolases are the ones that function similarly to esterases (except an ...
Akash Prakash Kanadje +3 more
core +1 more source
Advanced Science, EarlyView.An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang +9 more
wiley +1 more source
Synergistic action of the gut microbiota in environmental RNA interference in a leaf beetle
Microbiome, 2021 Background RNA interference (RNAi) has emerged as an efficient tool to control insect pests. When insects ingest double-stranded RNAs (dsRNAs) targeted against essential genes, strong gene silencing and mortality can be induced.
Letian Xu +6 more
doaj +1 more source
Biocatalysis in Spain: A field of success and innovation
, 2017 This is the presentation of the Special Issue “Biocatalysis in Spain”, covering the work of several Spanish groups in the field of Biocatalysis and Biotransformations.
Vicente Gotor +10 more
core +1 more source
Nanozymes expanding the boundaries of biocatalysis
Nature CommunicationsBiocatalysis is fundamental to biological processes and sustainable applications. Over time, the understanding of biocatalysis has evolved considerably.
Ruofei Zhang +3 more
doaj +1 more source
The Swiss Industrial Biocatalysis Consortium (SIBC) turns 20!
CHIMIAIn 2024, the Swiss Industrial Biocatalysis Consortium (SIBC), celebrated its 20 years of bringing together experts from the pharma, flavor and fragrance, fine chemicals, and agrochemicals industries to discuss enzyme technology developments.
Serena Bisagni +11 more
doaj +1 more source
Microbial Biocatalysis, 2nd Edition
Biocatalysis, leveraging the catalytic power of enzymes or whole microbial cells, has firmly established itself as a pivotal technology for sustainable chemical synthesis, environmental remediation, and the production of value-added compounds [...
Tao Pan, Zhilong Wang
core +1 more source