Results 71 to 80 of about 47,665 (229)

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

Advanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
wiley   +1 more source

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

Angewandte Chemie, EarlyView.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire, Wesley J. Olivier, Debabrata Maiti, Alex C. Bissember   +3 more
wiley   +2 more sources

Nanozymes expanding the boundaries of biocatalysis

Nature Communications
Biocatalysis is fundamental to biological processes and sustainable applications. Over time, the understanding of biocatalysis has evolved considerably.
Ruofei Zhang, Xiyun Yan, Lizeng Gao, Kelong Fan   +3 more
doaj   +1 more source

The Swiss Industrial Biocatalysis Consortium (SIBC) turns 20!

CHIMIA
In 2024, the Swiss Industrial Biocatalysis Consortium (SIBC), celebrated its 20 years of bringing together experts from the pharma, flavor and fragrance, fine chemicals, and agrochemicals industries to discuss enzyme technology developments.
Serena Bisagni, Fabian Eggimann, Eric Eichhorn, Steven Hanlon, Hans Iding, Alberto Kravina, Camille Le Chapelain, Katharina Neufeld, Lukas Rigger, Kirsten Schroer, Radka Snajdrova, Elina Siirola   +11 more
doaj   +1 more source

Synergistic action of the gut microbiota in environmental RNA interference in a leaf beetle

Microbiome, 2021
Background RNA interference (RNAi) has emerged as an efficient tool to control insect pests. When insects ingest double-stranded RNAs (dsRNAs) targeted against essential genes, strong gene silencing and mortality can be induced.
Letian Xu, Shijing Xu, Liuwei Sun, Yiqiu Zhang, Jing Luo, Ralph Bock, Jiang Zhang   +6 more
doaj   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors

Angewandte Chemie, EarlyView.
We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H. Vasilev, Eric R. Welin, Yichen Tan, Shane M. McKenna, Megan A. Emmanuel, Todd K. Hyster   +9 more
wiley   +2 more sources

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

Advanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen, Haidong Yu, Dongjiang Lin, Guojun Yang, Yuchen Xie, Yang Zhang, Jifeng Yuan   +6 more
wiley   +1 more source

Opportunities and challenges in the development of Cutaneotrichosporon oleaginosus ATCC 20509 as a new cell factory for custom tailored microbial oils

Microbial Cell Factories, 2017
Cutaneotrichosporon oleaginosus ATCC 20509, previously known as Trichosporon oleaginosus, Cryptococcus curvatus, Apiotrichum curvatum or Candida curvata D is an oleaginous yeast with several favorable qualities: it is fast growing, accumulates high ...
Felix Bracharz, Teun Beukhout, Norbert Mehlmer, Thomas Brück   +3 more
doaj   +1 more source

Bioconversion of eugenol into food flavouring agent vanillin [PDF]

, 2012
Microorganisms have the ability to chemically modify a wide variety of organic compounds by a process referred to as biological or microbial transformation, or in general, bioconversion.
Alok Somvanshi, Mahendra P. Darokar, Suaib Luqman, Suchita Srivastava, Sudeep Tandon, Suman P. S. Khanuja   +5 more
core   +2 more sources