Results 111 to 120 of about 3,482,455 (367)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Endogenous musculoskeletal tissue engineering - a focused perspective [PDF]

, 2012
Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient’s autologous cells ...
Adam, Clayton
core   +2 more sources

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits

, 2017
Retroactivity arises when the coupling of a molecular network $\mathcal{U}$ to a downstream network $\mathcal{D}$ results in signal propagation back from $\mathcal{D}$ to $\mathcal{U}$.
Deshpande, Abhishek, Ouldridge, Thomas E.   +1 more
core   +1 more source

Machine learning for biochemical engineering: A review

, 2021
M. Mowbray, Thomas R. Savage, Chufan Wu, Ziqi Song, B. A. Cho, E. A. Del Rio-Chanona, Dongda Zhang   +6 more
semanticscholar   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Probabilistic sensitivity analysis of biochemical reaction systems [PDF]

, 2009
Sensitivity analysis is an indispensable tool for studying the robustness and fragility properties of biochemical reaction systems as well as for designing optimal approaches for selective perturbation and intervention. Deterministic sensitivity analysis
Dempsey, William P., Goutsias, John, Zhang, Hong-Xuan   +2 more
core   +1 more source

Editorial: Women in chemical engineering

Frontiers in Chemical Engineering, 2023
Lisa R. Volpatti, Diana Bernin, Giulia Bozzano, Cristina Chuck-Hernandez, Siti Shawalliah Idris, Karla Mayolo-Deloisa   +5 more
doaj   +1 more source

Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude

Journal of Biological Engineering
Background For process development in mammalian cell cultivations, scale-up approaches are essential. A lot of studies concern the scale transfer between different-sized stirred tank reactors.
Anne Neuss, Thomas Steimann, Jacinta Sofia Tomas Borges, Robert Dinger, Jørgen Barsett Magnus   +4 more
doaj   +1 more source

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

Annals of Biomedical Engineering, 2011
During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs).
G. Aguilar, Bernard Choi, M. Broekgaarden, M. Broekgaarden, Owen Yang, Bruce Y. Yang, Pedram Ghasri, Jennifer K. Chen, R. Bezemer, J. Nelson, A. M. V. Drooge, A. Wolkerstorfer, K. Kelly, M. Heger, M. Heger   +14 more
semanticscholar   +1 more source