Results 121 to 130 of about 3,189,858 (352)
Combinatorial approach for improved cyanidin 3-O-glucoside production in Escherichia coli
Microbial Cell Factories, 2019 Background Multi-monocistronic and multi-variate vectors were designed, built, and tested for the improved production of cyanidin 3-O-glucoside (C3G) in Escherichia coli BL21 (DE3).
Biplav Shrestha +4 more
doaj +1 more source
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source
Microfluidics for Ultra High-Throughput Experimentation: Droplets, Dots & Photons [PDF]
arXiv, 2018 Andrew J. deMello is professor of Biochemical Engineering in the Department of Chemistry and Applied Biosciences at ETH Z\"urich. In this contribution he describes the efforts that his lab has undertaken in developing novel microfluidic systems for molecular and nanomaterial synthesis, droplet-based systems for ultra-high-throughput experimentation and
arxiv
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Protein engineering loops in aspartic proteinases: site-directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin [PDF]
, 1996 Philip G. Nugent +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Batched Stochastic Bayesian Optimization via Combinatorial Constraints Design [PDF]
arXiv, 2019 In many high-throughput experimental design settings, such as those common in biochemical engineering, batched queries are more cost effective than one-by-one sequential queries. Furthermore, it is often not possible to directly choose items to query.
arxiv
Biochemical engineering of the N-acyl side chain of sialic acid: biological implications [PDF]
, 2001 Oliver T. Keppler +4 more
openalex +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source