Results 121 to 130 of about 557,900 (328)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Optimisation of Biochemical Condition and Substrates In Vitro for Tissue Engineering of Ligament [PDF]

, 2006
S. Fawzi‐Grancher, N. de Isla, G Fauré, J.F. Stoltz, S. Müller   +4 more
openalex   +1 more source

Designer Gene Networks: Towards Fundamental Cellular Control

, 2001
The engineered control of cellular function through the design of synthetic genetic networks is becoming plausible. Here we show how a naturally occurring network can be used as a parts list for artificial network design, and how model formulation leads ...
Ackers, Arkin, Barkai, Becksei, Bialek, Bray, Chen, Dickson, Elowitz, Endy, Gardner, Gillespie, Glass, Glass, Glass, Hammond, Harada, Harding, Hartwell, Hasty, Jacob, Johnson, Johnson, Kauffman, Keller, Lauffenburger, Lowman, McAdams, McAdams, McAdams, McClure, Meyer, Monod, Monod, Moran, Novak, Novak, Novick, Ohlendorf, Palsson, Ptaschne, Reinitz, Rozanov, Samoilov, Sancho, Savageau, Savageau, Savageau, Shea, Smolen, Sveiczer, Szafranski, Tyson, Villaverde, von Hippel, Wolf, Wong   +56 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Molecular Interactions. On the Ambiguity of Ordinary Statements in Biomedical Literature [PDF]

, 2009
Statements about the behavior of biochemical entities (e.g., about the interaction between two proteins) abound in the literature on molecular biology and are increasingly becoming the targets of information extraction and text mining ...
Jansen, Ludger, Schulz, Stefan
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

The Cytochrome P450 Engineering Database: integration of biochemical properties [PDF]

, 2009
Demet Sirim, Florian Wagner, Andrey Lisitsa, Jürgen Pleiss   +3 more
openalex   +1 more source

Engineering a thixotropic and biochemically tunable hyaluronan and collagen bioink for biofabrication of multiple tissue construct types [PDF]

, 2021
Julio Aleman, Hemamylammal Sivakumar, Thomas J. DePalma, Yu Zhou, Andrea Mazzocchi, Richard Connor Huntwork, KyungMin Yoo, Surya R. Banks, Casey Clark, Alexandra Maycock, Kalan Leaks, Kevin Enck, Emmanuel C. Opara, Paul Gatenholm, Mark E. Welker, Shay Söker, Samuel Herberg, Tracy Criswell, Aleksander Skardal   +18 more
openalex   +1 more source

Hyaluronic acid alters vessel behavior in CXCL12-treated HUVECs [PDF]

, 2018
Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swelling, and altering solid stress of tumors. HA’s anionic behavior may provide important biochemical effects toward tumor progression as well.
Seibel, Alex J.
core  

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source