Results 91 to 100 of about 240,710 (295)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Motif Analysis for Small-Number Effects in Chemical Reaction Dynamics
, 2016 The number of molecules involved in a cell or subcellular structure is sometimes rather small. In this situation, ordinary macroscopic-level fluctuations can be overwhelmed by non-negligible large fluctuations, which results in drastic changes in ...
Kaneko, Kunihiko +2 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Computational challenges of systems biology [PDF]
, 2004 Progress in the study of biological systems such as the heart, brain, and liver will require computer scientists to work closely with life scientists and mathematicians.
Finkelstein, A. +6 more
core
The Dynamics of Zeroth-Order Ultrasensitivity: A Critical Phenomenon in Cell Biology
, 2011 It is well known since the pioneering work of Goldbeter and Koshland [Proc. Natl. Acad. Sci. USA, vol. 78, pp. 6840-6844 (1981)] that cellular phosphorylation- dephosphorylation cycle (PdPC), catalyzed by kinase and phosphatase under saturated condition ...
A. Goldbeter +18 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ANALOGIAS PARA O ENSINO DE BIOQUÍMICA NO NÍVEL MÉDIO
Ensaio Pesquisa em Educação em Ciências, 2012 The article aims to present a proposal for addressing issues of Biochemistry in high school by means of analogies, and assess the relevance of such a proposal from the students' written comments.
Jéssica Ulisses Barbosa +5 more
doaj
Comparative Assessment of Biochemical Parameters of Plants in Industrial and Non-Industrial Areas of Western Odisha, India [PDF]
Nature Environment and Pollution Technology, 2019 Industrialization being the main force of development has caused many changes not only in the global phenomena but also on a regional level through its ill effects on plants and animals.
Priyanka Priyadarshini and Chandan Sahu
doaj
Quantum chemistry reveals thermodynamic principles of redox biochemistry.
PLoS Computational Biology, 2018 Thermodynamics dictates the structure and function of metabolism. Redox reactions drive cellular energy and material flow. Hence, accurately quantifying the thermodynamics of redox reactions should reveal design principles that shape cellular metabolism.
Adrian Jinich +8 more
doaj +1 more source