Results 31 to 40 of about 88,052 (268)

Prediction of biological activity of spiroquinazolone derivatives as protein kinase inhibitors FGFR1 and CK2

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The purpose. The search for FGFR1 and CK2 protein kinase inhibitors were performed among spiroquinazolone derivatives using receptor-oriented virtual screening and in vitro biochemical testing using the human CK2 kinase domain.
O. K. Farat   +2 more
doaj   +1 more source

Emotions as Self-Organizational Factors of Anthropogenesis, Noogenesis and Sociogenesis

open access: yesAntropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2021
Purpose. The purpose is to prove the synchronicity of anthropogenesis, noogenesis and sociogenesis based on emotions, which are their self-organizational principles, as well as to reveal the synergistic essence of these processes. Theoretical basis.
І. M. Hoian, V. P. Budz
doaj   +1 more source

Migration dynamics of an important rice pest: The brown planthopper (Nilaparvata lugens) across Asia—Insights from population genomics

open access: yesEvolutionary Applications, 2020
Introduction Brown planthoppers (Nilaparvata lugens) are the most serious insect pests of rice, one of the world's most important staple crops. They reproduce year‐round in the tropical parts of their distribution, but cannot overwinter in the temperate ...
James P. Hereward   +5 more
doaj   +1 more source

In vivo molecular imaging in preclinical research

open access: yesLaboratory Animal Research, 2022
In vivo molecular imaging is a research field in which molecular biology and advanced imaging techniques are combined for imaging molecular-level biochemical and physiological changes that occur in a living body.
Su Jin Kim, Ho-Young Lee
doaj   +1 more source

Modelling physical processes in higher plants using leaf replicas for space applications

open access: yesComptes Rendus. Mécanique, 2023
In the future, higher plant cultivation will be a key component of Bioregenerative Life-Support Systems. This will require a deep understanding of phenomena that play an important role at the core of plant metabolism and of their interaction with the ...
Kuzma, Joanna   +3 more
doaj   +1 more source

Computational Modeling Intervertebral Disc Pathophysiology: A Review

open access: yesFrontiers in Physiology, 2022
Lower back pain is a medical condition of epidemic proportion, and the degeneration of the intervertebral disc has been identified as a major contributor.
Mallory Volz   +5 more
doaj   +1 more source

Is substaging necessary in patients with pathological stage T2 prostate cancer?

open access: yesUrology Research and Practice, 2019
Objective: To determine whether pathological T2 subgroups of prostate cancer can be predicted using preoperative data and to investigate whether there is any difference between pathological T2 subgroups in terms of biochemical recurrence.
Hasan Soydan   +5 more
doaj   +1 more source

Post mortem changes: challenges in drug analysis in the diagnosis of deaths from intoxication

open access: yesDrug Analytical Research, 2021
In forensic toxicology, alternative matrices and sampling sites are required for a correlation of antemortem and postmortem concentrations with the least possible error.
Marina Camargo Galera   +1 more
doaj   +7 more sources

Microfluidic Device for the Analysis of Angiogenic Sprouting under Bidirectional Biochemical Gradients

open access: yesMicromachines, 2020
In this paper, we developed a spheroid culture device that can trap a spheroid in the trapping site sandwiched by two extracellular matrix gels located at the upper and lower side of the spheroid.
Keigo Nishimura   +3 more
doaj   +1 more source

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