Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
MP35-02 COMPUTER-EXTRACTED FEATURES OF NUCLEAR AND GLANDULAR MORPHOLOGY FROM DIGITAL H&E TISSUE IMAGES PREDICT PROSTATE CANCER BIOCHEMICAL RECURRENCE AND METASTASIS FOLLOWING RADICAL PROSTATECTOMY [PDF]
, 2018 Patrick Leo +6 more
openalex +1 more source
Imaging Biochemical Recurrence in Prostate Cancer
Radiology: Imaging Cancer, 2021 openaire +2 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Histopathological Parameters Affecting Biochemical Recurrence in Radical Prostatectomies.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2017 WOS ...
Bal, Kaan +5 more
openaire +3 more sources
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
MP28-04 SENSITIVITY OF [-2]PROPSA (P2PSA) MEASUREMENTS FOR PREDICTION OF BIOCHEMICAL RECURRENCE (BCR) IN MEN AFTER RADICAL PROSTATECTOMY: A 3-YEARS PROSPECTIVE COHORT STUDY [PDF]
, 2017 Massimo Lazzeri +15 more
openalex +1 more source
Biochemical Prostate Cancer Recurrence Prediction: Thinking Fast & Slow
8 pages, 3 figures, methodology paper for LEOPRARD ...
You, Suhang +4 more
openaire +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
PD56-09 CAN FREE PSA BE USED AS A BIOMARKER IN BIOCHEMICAL RECURRENCE AFTER SURGERY TO PREDICT CASTRATE RESISTANT PROSTATE CANCER? [PDF]
, 2018 Hanan Goldberg +10 more
openalex +1 more source