Results 61 to 70 of about 1,905,672 (358)

A novel miRNA-based predictive model for biochemical failure following post-prostatectomy salvage radiation therapy. [PDF]

PLoS ONE, 2015
To develop a microRNA (miRNA)-based predictive model for prostate cancer patients of 1) time to biochemical recurrence after radical prostatectomy and 2) biochemical recurrence after salvage radiation therapy following documented biochemical disease ...
Erica Hlavin Bell, Simon Kirste, Jessica L Fleming, Petra Stegmaier, Vanessa Drendel, Xiaokui Mo, Stella Ling, Denise Fabian, Isabel Manring, Cordula A Jilg, Wolfgang Schultze-Seemann, Maureen McNulty, Debra L Zynger, Douglas Martin, Julia White, Martin Werner, Anca L Grosu, Arnab Chakravarti   +17 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence

Life, 2021
Currently, seven molecular subtypes of prostate cancer (PCa) are known, the most common of which being the subtype characterized by the presence of the TMPRSS2–ERG fusion transcript.
Anastasiya A. Kobelyatskaya, Elena A. Pudova, Anastasiya V. Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Zulfiya G. Guvatova, Maria V. Savvateeva, Nataliya V. Melnikova, Alexey A. Dmitriev, Dmitry Y. Trofimov, Gennady T. Sukhikh, Kirill M. Nyushko, Boris Y. Alekseev, Sergey V. Razin, George S. Krasnov, Anna V. Kudryavtseva   +15 more
doaj   +1 more source

Assessment of biochemical recurrence of prostate cancer (Review)

International Journal of Oncology, 2019
The assessment of the risk of biochemical recurrence (BCR) is critical in the management of males with prostate cancer (PC). Over the past decades, a comprehensive effort has been focusing on improving risk stratification; a variety of models have been constructed using PC‑associated pathological features and molecular alterations occurring at the ...
Lin, Xiaozeng, Kapoor, Anil, Gu, Yan, Chow, Mathilda Jing, Xu, Hui, Major, Pierre, Tang, Damu   +6 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Biochemical recurrence rates are similar for pT2-positive surgical margins and pT3a

International Brazilian Journal of Urology, 2014
Objective Histological details of positive surgical margins in radical prostatectomy specimens have been related to outcome after surgery in rare studies recently published.
Katia R. M. Leite, Carolina Hartmann, Sabrina T. Reis, Nayara Viana, Marcos F. Dall?Oglio, Alexandre C. Sant?Anna, Adriano Nesrallah, Luciano Nesrallah, Alberto A. Antunes, Luiz H. Camara-Lopes, Miguel Srougi   +10 more
doaj   +1 more source

Contrast-enhanced transrectal ultrasound can reduce collection of unnecessary biopsies when diagnosing prostate cancer and is predictive of biochemical recurrence following a radical prostatectomy in patients with localized prostate cancer

BMC Urology, 2020
Background To investigate the value of using contrast-enhanced transrectal ultrasound (CETRUS) to reduce unnecessary collection of biopsies during prostate cancer diagnosis and its utility in predicting biochemical recurrence in patients with localized ...
Hong-wei Zhao, Jian Li, Jia-Zheng Cao, Juan Lin, Zhu Wang, Jian-yao Lv, Jin-huan Wei, Zhen-hua Chen, Hao-hua Yao, Yi-hui Pan, Zhen-li Gao, Jun-hang Luo, Wei Chen, Lei Shi, Yong Fang   +14 more
doaj   +1 more source

MRI Characteristics Accurately Predict Biochemical Recurrence after Radical Prostatectomy

Journal of Clinical Medicine, 2020
Background: After radical prostatectomy (RP), biochemical recurrence (BCR) is associated with an increased risk of developing distant metastasis and prostate cancer specific and overall mortality.
C. Manceau, J. Beauval, M. Lesourd, C. Almeras, R. Aziza, J. Gautier, G. Loison, A. Salin, C. Tollon, M. Soulie, B. Malavaud, M. Roumiguié, G. Ploussard   +12 more
semanticscholar   +1 more source

Circulating microRNAs predict biochemical recurrence in prostate cancer patients [PDF]

British Journal of Cancer, 2013
Circulating microRNAs (miRNAs) are emerging as promising biomarkers for prostate cancer. Here, we investigated the potential of these molecules to assist in prognosis and treatment decision-making.MicroRNAs in the serum of patients who had experienced rapid biochemical recurrence (BCR) (n=8) or no recurrence (n=8) following radical prostatectomy (RP ...
Selth, L., Townley, S., Bert, A., Stricker, P., Sutherland, P., Horvath, L., Goodall, G., Butler, L., Tilley, W.   +8 more
openaire   +3 more sources