Results 191 to 200 of about 66,620 (264)

Photo‐Triggered, Fast, and Fluorogenic Thiophene‐Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3‐Dipole‐Tagged Molecules in No‐Wash Conditions

Angewandte Chemie, EarlyView.
Thiophene is king! The fusion of thiophene rings to cycloalkynes super‐charged their copper‐free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date) and (2) rendering the alkyne fluorogenic (with fluorescence enhancement up to 150‐fold upon reaction), making these bioorthogonal reagents ideal for tracking ...
Jurgen Schulz, Zoeisha S. Chinoy, Tarek Khalaf, Yukang Li, Pengchen Ma, Dennis Svatunek, Kendall N. Houk, Frédéric Friscourt   +7 more
wiley   +1 more source

Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates

Angewandte Chemie, EarlyView.
This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong, François Bénard, David M. Perrin   +2 more
wiley   +1 more source

Comprehensive genomic analysis reveals the class II diterpene cyclases in Dodonaea viscosa. [PDF]

Phytochemistry
Helwig K, Peters RJ.
europepmc   +1 more source

Allosteric Regulation of Photophysics and Binding in Oxazine‐macrocycle Complexes at Single‐molecule Resolution

Angewandte Chemie, EarlyView.
This work explores the interactions between the oxazine dye ATTO655 and two macrocyclic hosts using optical (single‑molecule) spectroscopy. Although ATTO655 forms a classical inclusion complex with cucurbit[8]uril (CB8), its interaction with p‑sulfonatocalix[4]arene (sCX4) leads to the formation of dim exclusion complexes.
Siyu Lu, Thomas‐Otavio Peulen, Hongbin Wu, Florian Lindemann, Despoina Kapiki, Rasmus Linser, Andreas Hennig, Thorben Cordes   +7 more
wiley   +1 more source

Cryo-EM maps of human DNA polymerase ε should be reevaluated in light of its unexpected behavior in vitro. [PDF]

Proc Natl Acad Sci U S A
Roske JJ, Yeeles JTP.
europepmc   +1 more source

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Angewandte Chemie, EarlyView.
Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher   +7 more
wiley   +1 more source

8th Int'l Conf.on Cytochrome P450 Biochemistry, Biophysics and Molecular Biology

Farumashia, 1993
openaire   +1 more source

CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia. [PDF]

Neoplasia
Prajapati SC, Meydan C, Neelamraju Y, Wang Z, Atwood G, Paudel BB, Fan H, Dunham N, Dillon R, Gandara JA, Lee T, Sheridan C, Wang S, Zumbo P, Becker MW, Bullinger L, Carroll MP, D'Andrea RJ, Levine RL, Mason CE, Melnick AM, Zang C, Bekiranov S, Garrett-Bakelman FE.   +23 more
europepmc   +1 more source

PHLDA1 silencing in IMR-32 human neuroblastoma cells results in ABCB1 overexpression, augments chemoresistance and leads to increased growth of tumors. [PDF]

Sci Rep
Kudrycka M, Horwacik I, Brożyna AA, Żywicka M, Durbas M, Rokita H.   +5 more
europepmc   +1 more source

High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals. [PDF]

J Am Chem Soc
Li R, Liu C, Li W, Truong MV, Khoo SW, Li Y, Merchant RR, Matsuura BS, Fung HYJ, Chen S, Qin T.   +10 more
europepmc   +1 more source